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Titolo:
Antimetastatic effect of hepatotropic liposomal adriamycin on human metastatic liver tumors
Autore:
Matsuda, I; Konno, H; Tanaka, T; Nakamura, S;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan
Titolo Testata:
SURGERY TODAY
fascicolo: 5, volume: 31, anno: 2001,
pagine: 414 - 420
SICI:
0941-1291(2001)31:5<414:AEOHLA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MAMMARY CARCINOMAS; DRUG-DELIVERY; ENCAPSULATED DOXORUBICIN; ADMINISTERED LIPOSOMES; LIPID-COMPOSITION; COLON-CANCER; THERAPY; CELLS; CARRIERS; MODEL;
Keywords:
hepatotropic liposome; galactose receptor; chemotherapy; liver metastasis; human colon cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuda, I Shimizu Municipal Hosp, Dept Surg, 1231 Miyakami, Shizuoka 4240911, Japan Shimizu Municipal Hosp 1231 Miyakami Shizuoka Japan 4240911 an
Citazione:
I. Matsuda et al., "Antimetastatic effect of hepatotropic liposomal adriamycin on human metastatic liver tumors", SURG TODAY, 31(5), 2001, pp. 414-420

Abstract

Adriamycin (ADM) was encapsulated in a galactose-conjugated hepatotropic liposome (hLip-ADM) and its ability to enhance the antitumor effect while reducing toxicity was compared with that of free ADM and a control Lip-ADM (cLip-ADM), in two in vitro animal models. Liver metastases were induced in rats by an intravenous injection of 8 x 10(6) AH-130 rat hepatoma tumor cells. All forms of the ADM completely inhibited liver metastasis when given ata dose of 5 mg/kg on day 14 after tumor implantation, whereas liver metastatic foci were observed in six of ten rats in the control group. The reduction in ADM toxicity by liposomalization was remarkable, as significant bodyweight loss was observed only in the free ADM group, in which four of ten rats died. Additional experiments utilized a human colon cancer xenograft (TK-4) to induce the growth of the liver metastases in mice by orthotopic implantation. The hLip-ADM completely inhibited liver metastasis in rats (0/11), whereas liver metastases developed in 10 of 12 mice in the control group and in 5 of 12 mice given cLip-ADM. Interestingly, liposomal ADM did not have a significant inhibitory effect on transplanted tumor growth assessed 6 weeks after transplantation. These findings indicate that hLip-ADM may bean effective strategy for inhibiting Liver metastases from human colon cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:33:03