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Titolo:
A new rating scale for age-related white matter changes applicable to MRI and CT
Autore:
Wahlund, LO; Barkhof, F; Fazekas, F; Bronge, L; Augustin, M; Sjogren, M; Wallin, A; Ader, H; Leys, D; Pantoni, L; Pasquier, F; Erkinjuntti, T; Scheltens, P;
Indirizzi:
Huddinge Univ Hosp, NEUROTEC, Dept Clin Neurosci, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 sci, S-14186 Huddinge, Sweden Huddinge Univ Hosp, Dept Radiol, Karolinska Inst, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 nst, S-14186 Huddinge, Sweden Vrije Univ Amsterdam, Neurosci Res Inst, Acad Ziekenhuis, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands huis, Amsterdam, Netherlands Karl Franzens Univ Graz, Dept Neurol, Graz, Austria Karl Franzens Univ Graz Graz Austria v Graz, Dept Neurol, Graz, Austria Karl Franzens Univ Graz, MR Ctr, Graz, Austria Karl Franzens Univ Graz Graz Austria s Univ Graz, MR Ctr, Graz, Austria Univ Gothenburg, Sect Psychiat, Inst Clin Neurosci, Molndal, Sweden Univ Gothenburg Molndal Sweden iat, Inst Clin Neurosci, Molndal, Sweden Vrije Univ Amsterdam, Fac Med, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands stat, Amsterdam, Netherlands Hop Roger Salengro, Serv Neurol Vasc, Lille, France Hop Roger Salengro Lille France lengro, Serv Neurol Vasc, Lille, France Univ Florence, Dept Neurol & Psychiat Sci, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 ychiat Sci, I-50121 Florence, Italy Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Memory Res Unit, Helsinki, Finland Univ Helsinki Helsinki Finland osci, Memory Res Unit, Helsinki, Finland
Titolo Testata:
STROKE
fascicolo: 6, volume: 32, anno: 2001,
pagine: 1318 - 1322
SICI:
0039-2499(200106)32:6<1318:ANRSFA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; LESIONS; DEMENTIA; ARTERIOLOSCLEROSIS; HYPERINTENSITIES; ROTTERDAM; CORRELATE; DEEP;
Keywords:
dementia; magnetic resonance imaging; rating scales; tomography, x-ray computed; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Wahlund, LO Huddinge Univ Hosp, NEUROTEC, Dept Clin Neurosci, B 56, S-14186 Huddinge, Sweden Huddinge Univ Hosp B 56 Huddinge Sweden S-14186 dinge, Sweden
Citazione:
L.O. Wahlund et al., "A new rating scale for age-related white matter changes applicable to MRI and CT", STROKE, 32(6), 2001, pp. 1318-1322

Abstract

Background and Purpose - MRI is more sensitive than CT for detection of age-related white matter changes (ARWMC), Most rating scales estimate the degree and distribution of ARWMC either on CT or on MRI, and they differ in many aspects. This makes it difficult to compare CT and MRI studies. To be able to study the evolution and possible effect of drug treatment on ARWMC inlarge patient samples, it is necessary to have a rating scale constructed for both MRI and CT. We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT. Methods - Seventy-seven patients with ARWMC on either CT or MRI were recruited and a complementary examination (MRI or CT) performed. The patients came from 4 centers in Europe, and the scans were rated by 4 raters on I occasion with the new ARWMC rating scale. The interrater reliability was evaluated by using K statistics. The degree and distribution of ARWMC in CT and MRI scans were compared in different brain areas. Results - Interrater reliability was good for MRI (kappa =0.67) and moderate for CT (kappa =0.48). MRI was superior in detection of small ARWMC, whereas larger lesions were detected equally well with both CT and MRI, In the parieto-occipital and infratentorial ai-eas, MRI detected significantly more ARWMC than did CT. In the frontal area and basal ganglia, no differences between modalities were found. When a fluid-attenuated inversion recovery sequence was used, MRI detected significantly more lesions than CT in frontal and parieto-occipital areas. No differences were found in basal ganglia and infratentorial areas. Conclusions - We present a new ARWMC scale applicable to both CT and MRI that has almost equal sensitivity, except for certain regions. The interrater reliability was slightly better for MRI, as was the detectability of small lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 13:13:25