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Titolo:
Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients.
Autore:
Dubertret, C; Gorwood, P; Gouya, L; Deybach, JC; Ades, J;
Indirizzi:
Hop Louis Mourier, AP HP, Serv Psychiat Adulte, Pr ADES, F-92701 Colombes,France Hop Louis Mourier Colombes France F-92701 ADES, F-92701 Colombes,France Univ Paris 07, CNRS, UMR 7593, Hop Salpetriere,Unite Personnal & ConduitesAdapt, F-75013 Paris, France Univ Paris 07 Paris France F-75013 ConduitesAdapt, F-75013 Paris, France Hop Louis Mourier, INSERM, U409, Lab Biochim,Federat Biol Mol,AP HP, F-92700 Colombes, France Hop Louis Mourier Colombes France F-92700 P HP, F-92700 Colombes, France
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 203 - 212
SICI:
0920-9964(20010415)49:1-2<203:AAEOTO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-D2 RECEPTOR GENE; LINKAGE DISEQUILIBRIUM; MOLECULAR VARIANT; FAMILY HISTORY; CYS311 VARIANT; NO ASSOCIATION; D2; POLYMORPHISM; LOCUS; SER311CYS;
Keywords:
dopamine D2 receptor gene; schizophrenia; haplotype; association study; HRR; TDT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Gorwood, P Hop Louis Mourier, AP HP, Serv Psychiat Adulte, Pr ADES, 178 Rue Renouillers, F-92701 Colombes, France Hop Louis Mourier 178 Rue Renouillers Colombes France F-92701
Citazione:
C. Dubertret et al., "Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients.", SCHIZOPHR R, 49(1-2), 2001, pp. 203-212

Abstract

The gene which codes for dopamine receptor D2 (DRD2) is considered as one of the most relevant candidate genes in schizophrenia. Previous genetic studies focusing on this gene gave conflicting results, potentially because ofthe differences in methodology (linkage versus association studies), and the different loci analyzed (the DRD2 gene having many polymorphisms). We used a progressive strategy with three different approaches (case/control, haplotype relative risk and transmission disequilibrium test) and investigated two genetic polymorphisms (TaqI B1/B2 and TaqI A1/A2. spanning the codingregion of the DRD2 gene) in 50 patients with DSM-IV diagnoses of schizophrenia, in their 100 parents and in 50 healthy, matched controls. Firstly, wefound a significant excess of the two alleles (B2 and A2) in the schizophrenic group compared to unaffected controls. Secondly, we found an excess oftransmission from the parents to their affected children, using the haplotype relative risk design applied to the B2A2 haplotype. Finally, the transmission disequilibrium test showed evidence for linkage between B2A2 haplotype and schizophrenia. The significant excess of the B2A2 haplotype in schizophrenic patients is specifically observed in a subsample of patients with a disease onset occurring after 20 years of age. As the haplotype contains nearly the entire DRD2 gene, we found convergent evidence in our sample fora significant role of the DRD2 gene in the risk for schizophrenia. This haplotype may be more specifically involved in the disorder's onset at a later age in some patients, or. alternatively, may be implicated as a modifyingfactor acting on age of onset. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 12:49:00