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Titolo:
Impact of prepulse characteristics on the detection of sensorimotor gatingdeficits in schizophrenia
Autore:
Braff, DL; Geyer, MA; Light, GA; Sprock, J; Perry, W; Cadenhead, KS; Swerdlow, NR;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 171 - 178
SICI:
0920-9964(20010415)49:1-2<171:IOPCOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; INFORMATION-PROCESSING DEFICITS; STARTLE REFLEX; INHIBITION DEFICITS; ACOUSTIC STARTLE; ANIMAL-MODEL; HABITUATION; STIMULATION; MODULATION; ATTENTION;
Keywords:
gating; prepulse inhibition; schizophrenia; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Braff, DL Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
D.L. Braff et al., "Impact of prepulse characteristics on the detection of sensorimotor gatingdeficits in schizophrenia", SCHIZOPHR R, 49(1-2), 2001, pp. 171-178

Abstract

Schizophrenia patients have prominent deficits in information processing that can be detected by measures of prepulse inhibition (PPI) of the startleresponse. Deficient PPI in schizophrenia is thought to reflect a failure of brain-based information 'protective' mechanisms that normally inhibit responsivity for 30-500 ms after a weak prepulse stimulus. The relationship between specific prepulse stimulus characteristics and PPI deficits in this study was examined in 31 schizophrenia patients and 34 normal comparison subjects, Schizophrenia patients had overall deficits in PPI across four conditions where the prepulse was either discrete (abrupt) or continuous (sustained) and consisted of either white noise or a pure tone. On inspection and analysis of the data. it appears that the white noise conditions, rather than tone conditions, account for the group differences. Thus, the discrete white noise prepulse was most effective in eliciting PPI deficits, resultingin a large effect size between groups (d = 0.85; P < 0.01). Deficits in information-protective mechanisms in schizophrenia may be differentially sensitive to specific stimulus characteristics; this observation may be relevant both to the neurobiology of information processing deficits in schizophrenia and to the methodologies for studying these deficits experimentally. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:59:43