Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Conditioned blocking and schizophrenia: a replication and study of the role of symptoms, age, onset-age of psychosis and illness-duration
Autore:
Bender, S; Muller, B; Oades, RD; Sartory, G;
Indirizzi:
Univ Essen Gesamthsch, Clin Child & Adolescent Psychiat & Psychotherapy, D-45147 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45147 rapy, D-45147 Essen, Germany Univ Essen Gesamthsch, Clin Psychiat & Psychotherapy, D-45147 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45147 rapy, D-45147 Essen, Germany Berg Univ Gesamthsch Wuppertal, Dept Clin Psychol, D-42097 Wuppertal, Germany Berg Univ Gesamthsch Wuppertal Wuppertal Germany D-42097 pertal, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 157 - 170
SICI:
0920-9964(20010415)49:1-2<157:CBASAR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; LATENT INHIBITION; KAMIN BLOCKING; MONOAMINE METABOLISM; PREPULSE INHIBITION; PERFORMANCE; AMPHETAMINE; DYSFUNCTION; PERSONALITY; ATTENTION;
Keywords:
attention; blocking; illness-duration; onset; nonparanoid schizophrenia; paranoid; thought disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Oades, RD Univ Essen Gesamthsch, Clin Child & Adolescent Psychiat & Psychotherapy, Virchowstr 174, D-45147 Essen, Germany Univ Essen Gesamthsch Virchowstr 174 Essen Germany D-45147 many
Citazione:
S. Bender et al., "Conditioned blocking and schizophrenia: a replication and study of the role of symptoms, age, onset-age of psychosis and illness-duration", SCHIZOPHR R, 49(1-2), 2001, pp. 157-170

Abstract

Measures of selective attention processing like latent inhibition (LI) andconditioned blocking (CB) are disturbed in some patients with schizophrenia. [LI is the delay in learning about the associations of a stimulus that has been associated with no event (versus de novo learning); CB is the delayin learning the associations of a stimulus-component when the other component has already started to acquire these associations.] We proposed: (1) toreplicate the reported decreases of CB in patients without paranoid-hallucinatory symptoms; (2) to see if CB depends on the age of illness-onset and its duration, as reported for LI. We studied 101 young and old, acute and chronically ill patients with schizophrenia, of whom 62 learned a modified 'mouse-inhouse' CB task, and compared them with 62 healthy controls matched for age, education and socio-economic background. CB was more evident in patients with a diagnosis of paranoid schizophrenia than other subtypes, An unusual persistence of high CB scores through testing was associated with productive symptoms (including positive thought disorder). Reduced CB relatedto the expression of (a) Schneider's first rank symptoms of ideas-of-reference and (b) to negative symptoms like poor rapport and poor attention. CB was less evident in the older patients and those with an earlier illness-onset. In contrast to the similar LI test of selective attention, CB is foundin patients with paranoid schizophrenia and its expression is not related closely to illness duration, This implies that the two tests reflect the activity of different underlying processes. We suggest that reduced CB on initial test-trials in nonparanoid schizophrenia reflects the unusual persistence of controlled information processing strategies that would normally become automatic during conditioning. In contrast, continued CB during testingreflects an unusual persistence of automatic processing strategies. (C) 2001 Elsevier Science B,V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:32:01