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Titolo:
An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia
Autore:
Winterer, G; Egan, MF; Radler, T; Hyde, T; Coppola, R; Weinberger, DR;
Indirizzi:
NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Disorders Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 129 - 143
SICI:
0920-9964(20010415)49:1-2<129:AABRIE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ELECTROENCEPHALOGRAM EEG; TO-NOISE RATIO; SIBLINGS DISCORDANT; HEALTHY-VOLUNTEERS; LINKAGE STRATEGIES; NEGATIVE SYMPTOMS; ACTIVATION TASKS; COMPLEX TRAITS; BLOOD-FLOW; POWER;
Keywords:
coherence; EEG; relative risk; schizophrenia; sib-pair analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Winterer, G NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USANIMH Bethesda MD USA 20892 ranch, NIH, Bethesda, MD 20892 USA
Citazione:
G. Winterer et al., "An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia", SCHIZOPHR R, 49(1-2), 2001, pp. 129-143

Abstract

Previous studies have suggested that schizophrenic patients show resting EEG replicate the results on the second data set. power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5 Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (hs) ranged between 3.7 and 9.8, depending on phenotype definition. Thus, while power spectrum EEG abnormalities may be state-dependent, reduced coherence as a possible measure ofneuronal synchronization is familial and potentially a heritable trait related to genetic risk for schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/01/20 alle ore 18:58:17