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Titolo:
P300 amplitude as a possible correlate of frontal degeneration in schizophrenia
Autore:
Martin-Loeches, M; Molina, V; Munoz, F; Hinojosa, JA; Reig, S; Desco, M; Benito, C; Sanz, J; Gabiri, A; Sarramea, F; Santos, A; Palomo, T;
Indirizzi:
Univ Complutense, Pluridisciplinary Inst, Brain Mapping Unit, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 apping Unit, E-28040 Madrid, Spain Univ Complutense, Dept Psychiat, Hosp 12 Octubre, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 12 Octubre, E-28040 Madrid, Spain Hosp Gen Gregorio Maranon, Dept Expt Med, Madrid, Spain Hosp Gen Gregorio Maranon Madrid Spain on, Dept Expt Med, Madrid, Spain Hosp Gen Gregorio Maranon, Dept Neuroradiol, Madrid, Spain Hosp Gen Gregorio Maranon Madrid Spain Dept Neuroradiol, Madrid, Spain Hosp Reina Sofia, Dept Psychiat, Cordoba, Spain Hosp Reina Sofia CordobaSpain ina Sofia, Dept Psychiat, Cordoba, Spain Univ Politecn Madrid, ETSI Telecomunicac, Madrid, Spain Univ Politecn Madrid Madrid Spain id, ETSI Telecomunicac, Madrid, Spain
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 121 - 128
SICI:
0920-9964(20010415)49:1-2<121:PAAAPC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; VOLUME REDUCTION; ABNORMALITIES; ONSET; PSYCHOPATHOLOGY; MEDICATION; STIMULUS; STATE; EEG; ERP;
Keywords:
event-related electrical potentials; neurodegeneration; P300 amplitude; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Martin-Loeches, M Univ Complutense, Pluridisciplinary Inst, Brain Mapping Unit, Po Juan XXIII,1, E-28040 Madrid, Spain Univ Complutense Po Juan XXIII,1 Madrid Spain E-28040 n
Citazione:
M. Martin-Loeches et al., "P300 amplitude as a possible correlate of frontal degeneration in schizophrenia", SCHIZOPHR R, 49(1-2), 2001, pp. 121-128

Abstract

The existence of neurodegeneration is a debated issue in schizophrenia research. The P300 component of event-related electrical potentials (ERP) has been related to the different degree of damage to gray and white matter. This study explores the possible relationship between P300 amplitude and/or latency and the existence of degenerative processes in schizophrenia, by assessing its correlation with volume of sulcal CSF and duration of illness, as transversal indicators of neurodegeneration, Nineteen patients (14 males,5 females) and 13 controls (6 males, 7 females) were studied with MRI and electrophysiologic al records (P300). The possible influence of sex and ageat the time of the exploration was statistically controlled in both groups. The results show a significant negative correlation between P300 amplitude and prefrontal CSF volume in the patient group. A lower though still significant correlation was also found between P300 amplitude and duration of illness, whereas no correlation was found in the control group. These results support the hypothesis that P300 amplitude may be interpreted as a markerof neurodegeneration in schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:03:48