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Titolo:
Corpus callosum and P300 in schizophrenia
Autore:
Frodl, T; Meisenzahl, EM; Muller, D; Greiner, J; Juckel, G; Leinsinger, G; Hahn, H; Moller, HJ; Hegerl, U;
Indirizzi:
Univ Munich, Dept Psychiat, Clin Neurophysiol Lab, D-80336 Munich, GermanyUniv Munich Munich Germany D-80336 ophysiol Lab, D-80336 Munich, Germany Univ Munich, Dept Radiol, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 Dept Radiol, D-80336 Munich, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 107 - 119
SICI:
0920-9964(20010415)49:1-2<107:CCAPIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; NUCLEAR MAGNETIC-RESONANCE; BIPOLAR AFFECTIVE-DISORDER; AUDITORY P300; NEGATIVE SYMPTOMS; BRAIN MORPHOLOGY; ABNORMALITIES; SIZE; HANDEDNESS; CLOZAPINE;
Keywords:
cortical disorganization; interhemispheric transfer; P300; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Frodl, T Univ Munich, Dept Psychiat, Clin Neurophysiol Lab, Nussbaumstr 7,D-80336 Munich, Germany Univ Munich Nussbaumstr 7 Munich Germany D-80336 Munich, Germany
Citazione:
T. Frodl et al., "Corpus callosum and P300 in schizophrenia", SCHIZOPHR R, 49(1-2), 2001, pp. 107-119

Abstract

Functional abnormalities in the interhemispheric transfer via the corpus callosum in schizophrenia may result in filtering problems and information processing problems, which may in turn be related to the synchronization of cortical event-related activity. To explore whether a relationship exists between corpus callosum (CC) size, measured with in-vivo magnetic resonance imaging, and late auditory event-related P300 potentials, 50 patients with schizophrenia as well as 50 healthy controls were examined. The absolute CCsize and subregional areas, as well as the CC areas adjusted for total brain volume, were not significantly different between patients with schizophrenia acid controls. While no significant group differences were observed for P3a-. P3b-. PSW-amplitudes and P3b-latencies. P3a- and PSW-latencies weresignificantly prolonged for patients with schizophrenia. Absolute CC totalsize was significantly correlated with P3b-amplitudes in healthy controls (r = 0.29: P = 0.044). In patients with schizophrenia, significant correlations were observed between the subregion of the posterior body of the CC and positive slow wave (PSW: r = 0.47; P = 0.001). P3a-. P3b- and PSW-latencies were not significantly correlated to CC size in either patients with schizophrenia or healthy controls. The results are discussed in terms of the possibility that abnormalities in interhemispheric transfer may underlie themechanisms of schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 14:04:19