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Titolo:
Vulnerability to involuntary movements over a lifetime trajectory of schizophrenia approaches 100%, in association with executive (frontal) dysfunction
Autore:
Quinn, J; Meagher, D; Murphy, P; Kinsella, A; Mullaney, J; Waddington, JL;
Indirizzi:
St Davnets Hosp, Stanley Fdn, Res Unit, Monaghan, Ireland St Davnets HospMonaghan Ireland anley Fdn, Res Unit, Monaghan, Ireland St Itas Hosp, Portrane, Dublin, Ireland St Itas Hosp Portrane Dublin Ireland tas Hosp, Portrane, Dublin, Ireland St Lomans Hosp, Mullingar, Westmeath, Ireland St Lomans Hosp Mullingar Westmeath Ireland Mullingar, Westmeath, Ireland Dublin Inst Technol, Dept Math, Dublin 8, Ireland Dublin Inst Technol Dublin Ireland 8 chnol, Dept Math, Dublin 8, Ireland Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal CollSurg Ireland Dublin Ireland 2 in Pharmacol, Dublin 2, Ireland
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 79 - 87
SICI:
0920-9964(20010415)49:1-2<79:VTIMOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; TARDIVE-DYSKINESIA; COGNITIVE IMPAIRMENT; NEGATIVE SYMPTOMS; BASAL GANGLIA; RISK-FACTORS; NEVER; DISORDERS; NEUROPATHOLOGY; NEUROLEPTICS;
Keywords:
cognitive dysfunction; executive dyscontrol; involuntary movements; tardive dyskinesia; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL St Davnets Hosp, Stanley Fdn, Res Unit, Monaghan, Ireland St Davnets Hosp Monaghan Ireland Unit, Monaghan, Ireland
Citazione:
J. Quinn et al., "Vulnerability to involuntary movements over a lifetime trajectory of schizophrenia approaches 100%, in association with executive (frontal) dysfunction", SCHIZOPHR R, 49(1-2), 2001, pp. 79-87

Abstract

This study assessed the prevalence of involuntary movements among older inpatients with severe schizophrenia, many of whom had experienced a lifetimeof illness and its treatment, and examined their neuropsychological correlates. The subjects of this study were 128 inpatients with a DSM-IV diagnosis of schizophrenia. They were assessed using the Abnormal Involuntary Movement Scale, the Mini-Mental State Examination for general cognitive impairment and the Executive Interview for executive dyscontrol; additionally, their medical records were reviewed in detail for treatment histories. Prevalence of involuntary movements was examined and their clinical correlates determined in relation to topography of movement disorder using logistic regression. In schizophrenia, prevalence of involuntary movements was: age < 65 years, 63%; 65-75 years. 80%; > 75 years, 93%. The primary correlate both ofoverall and of orofacial movements was poor executive function, whereas the primary correlate of limb-trunkal movements was poor general cognitive function. On approaching the limits of human longevity following a lifetime trajectory of illness and its treatment, essentially 'all' patients with schizophrenia appear inherently vulnerable to the emergence of involuntary movements in topographically specific association with cognitive deficits. (C)2001 Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:33:43