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Titolo:
A review of MRI findings in schizophrenia
Autore:
Shenton, ME; Dickey, CC; Frumin, M; McCarley, RW;
Indirizzi:
Harvard Univ, Sch Med, Dept Psychiat, Lab Neurosci,Clin Neurosci Div, Brockton, MA 02301 USA Harvard Univ Brockton MA USA 02301 n Neurosci Div, Brockton, MA 02301 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 1 - 52
SICI:
0920-9964(20010415)49:1-2<1:AROMFI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; CHILDHOOD-ONSET SCHIZOPHRENIA; SUPERIOR TEMPORAL GYRUS; GRAY-MATTER VOLUME; CAVUM-SEPTUM-PELLUCIDUM; SCHIZOTYPAL PERSONALITY-DISORDER; CORPUS-CALLOSUM SIZE; RESONANCE-IMAGING ABNORMALITIES; STRUCTURAL BRAIN ABNORMALITIES; MONOZYGOTIC TWINS DISCORDANT;
Keywords:
schizophrenia; magnetic resonance imaging; MRI; psychosis; first episode schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
489
Recensione:
Indirizzi per estratti:
Indirizzo: Shenton, ME Harvard Univ, Sch Med, Dept Psychiat, Lab Neurosci,Clin Neurosci Div, Brockton, MA 02301 USA Harvard Univ Brockton MA USA 02301 iv, Brockton, MA 02301 USA
Citazione:
M.E. Shenton et al., "A review of MRI findings in schizophrenia", SCHIZOPHR R, 49(1-2), 2001, pp. 1-52

Abstract

After more than 100 years of research, the neuropathology of schizophreniaremains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin, E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York),who first described 'dementia praecox' and the schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study mon tractable brain diseases. The results of subsequent neuropathological studieswere disappointing because of conflicting findings. Research interest thuswaned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magneticresonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon. M., Ravichandran,G.K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia. The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advanceshave now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier post-mortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medialtemporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus. and parahippocampal gyrus, and neocortical temporal loberegions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter andorbitofrontal regions. Similarly. there was moderate evidence for parietallobe abnormalities (60% of studies reviewed), particularly of the inferiorparietal lobule which includes both supramarginal and angular gyri. Additionally, there was strong to moderate evidence for subcortical abnormalities(i.e. cavum septi pellucidi-92% of studies reviewed, basal ganglia-68% of studies reviewed, corpus callosum-63% of studies reviewed, and thalamus-42%of studies reviewed), but more equivocal evidence for cerebellar abnormalities (31% of studies reviewed).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:34:38