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Titolo:
Faecal elastase-1: Lyophilization of stool samples prevents false low results in diarrhoea
Autore:
Fischer, B; Hoh, S; Wehler, M; Hahn, EG; Schneider, HT;
Indirizzi:
Univ Erlangen Nurnberg, Med Klin & Poliklin 1, Dept Med 1, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 36, anno: 2001,
pagine: 771 - 774
SICI:
0036-5521(200107)36:7<771:FELOSS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC FUNCTION-TEST; CLINICAL-EVALUATION; FECAL ELASTASE-1; DIAGNOSIS;
Keywords:
chronic pancreatitis; diarrhoea; lyophilization; pancreatic elastase-1; pancreatic function test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, HT Univ Erlangen Nurnberg, Med Klin & Poliklin 1, Dept Med 1, Krankenhausstr 12, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Krankenhausstr 12 Erlangen Germany D-91054
Citazione:
B. Fischer et al., "Faecal elastase-1: Lyophilization of stool samples prevents false low results in diarrhoea", SC J GASTR, 36(7), 2001, pp. 771-774

Abstract

Background: In patients with diarrhoea, fat:cal elastase-l is used to detect exocrine pancreatic insufficiency. Diarrhoea is defined as > 85% stool water content. Methods: We analysed elastase-1 in 519 stool samples from 310patients unprocessed as well as after lyophilization in a standard laboratory lyophilizator. Stool water content was calculated by weight difference before and after lyophilization. Results: 151 stool samples were classifiedas 'diarrhoea' (mean stool water content 88.8%); all others had a mean water content of 75.4%. In the 'diarrhoea' samples, elastase-l levels were considerably higher after lyophilization-with a calculated normal water content of 75% (606 +/- 359 mug/g, mean +/- s)-compared to measurement when unprocessed (279 +/- 151 mug/g; P < 0.0001). In 16 of the 151 cases (11%), the abnormally low elastase-1 level below 200 mug/g found in unprocessed stools proved normal (> 200 mug/g) after Lyophilization and correction for stool water content. Conclusion: Diarrhoea can result in falsely decreased elastase-1 Levels in a number of patients with non-pancreatogenic diarrhoea. Lyophilization is a simple measure by which to determine elastase-1 independently of stool water content. Lyophilization of stool samples can therefore help to prevent wrong positive elastase-1 test results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:00:24