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Titolo:
Erythropoietic response to hypoxaemia in diffuse idiopathic pulmonary fibrosis, as opposed to chronic obstructive pulmonary disease
Autore:
Tassiopoulos, S; Kontos, A; Konstantopoulos, K; Hadzistavrou, C; Vaiopoulos, G; Aessopos, A; Tassiopoulos, T;
Indirizzi:
Univ Athens, Sch Med, Dept Internal Med 1, Laikon Hosp, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 Laikon Hosp, GR-11527 Athens, Greece Chest Dis Hosp, Dept Chest Med, Athens, Greece Chest Dis Hosp Athens Greece t Dis Hosp, Dept Chest Med, Athens, Greece
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 6, volume: 95, anno: 2001,
pagine: 471 - 475
SICI:
0954-6111(200106)95:6<471:ERTHID>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-DISEASE; POLYCYTHEMIA; SERUM;
Keywords:
diffuse idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; erythrocytosis; erythropoietin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Konstantopoulos, K Univ Athens, Sch Med, Dept Internal Med 1, Laikon Hosp,GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 527 Athens, Greece
Citazione:
S. Tassiopoulos et al., "Erythropoietic response to hypoxaemia in diffuse idiopathic pulmonary fibrosis, as opposed to chronic obstructive pulmonary disease", RESP MED, 95(6), 2001, pp. 471-475

Abstract

The aim of this study was to assess the erythropoietic response to hypoxaemia in patients with diffuse idiopathic pulmonary fibrosis (DIPF), and to speculate on the underlying mechanisms. Patients on an established chronic respiratory failure due to DIPF or chronic obstructive pulmonary disease (COPD) were studied. The erythropoietic response to hypoxaemia in both conditions was assessed. We studied 18 patients with DIPF and 29 patients with COPD in respiratory failure in a stable stage, free from acute infection and congestive heart failure. Blood gases, erythrocytic parameters, as well the serum levels of iron, ferritin and erythropoietin were determined.ll the DIPF patients studied, apart from two, had normal or subnormal haematocrit values. The patients with COPD had an inconsistant response to hypoxaemia; 12 had normal or subnormal haematocrit values and the remaining 17 were erythraemic. The mean value of erythropoietin (EPO) in both DIPF and COPD patients was significantly higher than normal. In conclusion, patients with DIPF exhibit a lack of erythropoietic response to hypoxaemia, despite the augmented erythropoietin levels. This may reflect a defective bone marrow erythropoietic response in DIPF patients. It issuggested that the pathophysiology of DIPF underlies this mechanism.

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Documento generato il 01/10/20 alle ore 16:06:19