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Titolo:
Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice
Autore:
Fielden, MR; Halgren, RG; Tashiro, CHM; Yeo, BR; Chittim, B; Chou, K; Zacharewski, TR;
Indirizzi:
Michigan State Univ, Dept Biochem & Mol Biol, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 l Ctr, E Lansing, MI 48824 USA Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA Michigan StateUniv E Lansing MI USA 48824 m Sci, E Lansing, MI 48824 USA Michigan State Univ, Inst Environm Toxicol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 xicol, E Lansing, MI 48824 USA Michigan State Univ, Inst Int Hlth, E Lansing, MI 48824 USA Michigan StateUniv E Lansing MI USA 48824 Hlth, E Lansing, MI 48824 USA Wellington Labs, Guelph, ON, Canada Wellington Labs Guelph ON CanadaWellington Labs, Guelph, ON, Canada
Titolo Testata:
REPRODUCTIVE TOXICOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 281 - 292
SICI:
0890-6238(200105/06)15:3<281:EOGALE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENER-SPECIFIC ANALYSIS; POLYCHLORINATED-BIPHENYLS; POSTNATAL EXPOSURE; HORMONE LEVELS; PCB MIXTURE; TESTIS; RATS; TRANSTHYRETIN; BINDING; WEIGHTS;
Keywords:
Aroclor 1242; in vitro fertilization; polychlorinated biphenyls; sperm count; testis; fertility; CASA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Zacharewski, TR Michigan State Univ, Dept Biochem & Mol Biol, Natl Food Safety & Toxicol Ctr, 223 Biochem Bldg,Wilson Rd, E Lansing, MI 48824 USA Michigan State Univ 223 Biochem Bldg,Wilson Rd E Lansing MI USA 48824
Citazione:
M.R. Fielden et al., "Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice", REPROD TOX, 15(3), 2001, pp. 281-292

Abstract

The objective of this study was to examine the effects of gestational and lactational exposure to Aroclor 1242 (0, 10, 25, 50, and 100 mg/kg-bw) on male fertility. Doses were administered to C57BL6 female mice orally every two days from two weeks before mating, during mating, and through gestation until postnatal day 21. Male B6D2F1 offspring were examined for anogenital distance, organ development. epididymal sperm count, sperm motility, and invitro fertility at 16 and 45 weeks of age. Stomach samples of pups nursingfrom PCB-treated mothers in the 50 mg/kg dose group were analyzed for PCBsand chlorobiphenylols by high resolution gas chromatography coupled with low resolution mass spectrometry. It was estimated that the nursing pups were exposed to 0.2, 0.6, 1.2, and 2.4 mg/kg/day total PCBs in the 10, 25, 50,and 100 mg/kg dose groups, respectively. This exposure level approaches the maximum FDA recommended levels for PCBs in food and breast milk. The composition of the PCBs in the stomach samples was different from the parent mixture, as there was a higher proportion of heavily chlorinated congeners. as well as chlorobiphenylols. Anogenital distance at weaning, and liver, thymus, and testes weight at 16 and 45 weeks of age were not affected by PCB exposure. Epididymal sperm velocity and linearity were significantly increased in the 25 mg/kg dose group at 16 weeks of age. Sperm count was increasedby 36% in this dose group (P = 0.06). By 45 weeks of age, average sperm count in this dose group was similar to that of controls. With the exception of the 50 mg/kg dose group at 16 weeks of age, sperm fertilizing ability invitro was significantly decreased in all PCB-exposed groups at 16 and 45 weeks of age. These results suggest that fertility in the adult mouse is susceptible to developmental exposure to Aroclor 1242 and is independent of testis weight or epididymal sperm count. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:19:18