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Titolo:
Impaired final follicular maturation in heifers after superovulation with recombinant human FSH
Autore:
Takagi, M; Kim, IH; Izadyar, F; Hyttel, P; Bevers, MM; Dieleman, SJ; Hendriksen, PIM; Vos, PLAM;
Indirizzi:
Univ Utrecht, Fac Med Vet, Dept Farm Anim Hlth, NL-3584 CL Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CL 3584 CL Utrecht, Netherlands Obihiro Univ Agr & Vet Med, Fac Med Vet, Obihiro, Hokkaido 0800835, Japan Obihiro Univ Agr & Vet Med Obihiro Hokkaido Japan 0800835 0800835, Japan Chungbuk Natl Univ, Dept Vet Med, Cheongju, South Korea Chungbuk Natl Univ Cheongju South Korea Vet Med, Cheongju, South Korea Royal Vet & Agr Univ, Dept Anat & Physiol, Frederiksberg C, Denmark Royal Vet & Agr Univ Frederiksberg Denmark C l, Frederiksberg C, Denmark
Titolo Testata:
REPRODUCTION
fascicolo: 6, volume: 121, anno: 2001,
pagine: 941 - 951
SICI:
1470-1626(200106)121:6<941:IFFMIH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREOVULATORY LH SURGE; DOSE-RESPONSE TRIAL; STIMULATING-HORMONE; LUTEINIZING-HORMONE; EMBRYO PRODUCTION; OOCYTE MATURATION; HOLSTEIN COWS; TREATED COWS; BEEF HEIFERS; DAIRY-COWS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Vos, PLAM Univ Utrecht, Fac Med Vet, Dept Farm Anim Hlth, Yalelaan 7, NL-3584 CL Utrecht, Netherlands Univ Utrecht Yalelaan 7 Utrecht Netherlands NL-3584 CL herlands
Citazione:
M. Takagi et al., "Impaired final follicular maturation in heifers after superovulation with recombinant human FSH", REPRODUCT, 121(6), 2001, pp. 941-951

Abstract

The aim of this study was to investigate whether human FSH without contaminating LH can exert a normal superovulation response in cows. One group of heifers (n = 9) was stimulated with recombinant human FSH (rhFSH), an FSH source without any LH activity, and another group (n = 9) was treated with equine chorionic gonadotrophin (eCG), an FSH source with high LH activity. Daily transrectal ultrasonography showed that eCG- and rhFSH-stimulated heifers (n = 9 per group) had the same follicular growth characteristics and equal numbers of follicles > 8 mm in diameter after 3 days of stimulation. The treatment groups differed considerably in steroid production: rhFSH-treated heifers produced much lower oestradiol concentrations than did eCG-stimulated heifers during the first days of stimulation and much lower progesterone concentrations in the period after the LH surge. During the 27-35 h after prostaglandin injection, rhFSH-treated heifers had fewer LH pulses than did eCG-treated heifers (0.3 versus 3.0 per heifer, respectively; n = 3 pergroup). All rhFSH-treated heifers (n = 6) underwent a preovulatory LH surge, but this occurred significantly later than in the eCG-treated heifers (n= 4; 39.4 +/- 1.9 h versus 47.1 +/- 1.5 h in rhFSH- and eCG-treated heifers, respectively). Multiple ovulations occurred in only three of six rhFSH-treated heifers, but in all four eCG-treated heifers with an LH surge. At 24h after the LH surge, the percentage of metaphase II stage oocytes with cortical granules distributed close to the oolemma was significantly lower inthe rhFSH group (7.3%) than in the eCG group (55.9%). In conclusion, finalfollicular maturation is impaired in heifers treated with rhFSH, which might be due to the combination of a lack of LH activity in the gonadotrophin preparation and the severe suppression of LH pulsatility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:03:40