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Titolo:
Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats
Autore:
Pinilla, L; Gonzalez, LC; Gaytan, F; Tena-Sempere, M; Aguilar, E;
Indirizzi:
Univ Cordoba, Fac Med, Dept Physiol, Cordoba 14004, Spain Univ Cordoba Cordoba Spain 14004 Med, Dept Physiol, Cordoba 14004, Spain
Titolo Testata:
REPRODUCTION
fascicolo: 6, volume: 121, anno: 2001,
pagine: 915 - 924
SICI:
1470-1626(200106)121:6<915:OEONAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPUBERAL REPRODUCTIVE DEFECTS; ESTROGEN-RECEPTOR MODULATOR; SERTOLI CELLS; SYNAPTIC PLASTICITY; ESTRADIOL BENZOATE; SERUM-CHOLESTEROL; ANDROGEN EXPOSURE; ARCUATE NUCLEUS; ADULT; ANTIESTROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Pinilla, L Univ Cordoba, Fac Med, Dept Physiol, Avda Menendez Pidal S-N, Cordoba 14004, Spain Univ Cordoba Avda Menendez Pidal S-N Cordoba Spain 14004 Spain
Citazione:
L. Pinilla et al., "Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats", REPRODUCT, 121(6), 2001, pp. 915-924

Abstract

Selective oestrogen receptor modulators constitute a family of drugs that are used increasingly in the management of oestrogen-associated pathology. Raloxifene is a selective oestrogen receptor modulator that is used to treat and prevent osteoporosis in post-menopausal women. The actions of raloxifene on bone, breast, uterus and serum cholesterol concentrations have been widely analysed, but very few studies have investigated the possible actions of this drug on the central nervous system. The central nervous system ofthe newborn rat is very sensitive to oestrogen action. In this study a series of experiments was conducted to analyse the effects of different doses of raloxifene (50, 100, 250 or 500 mug per rat per day) administered to neonatal rats on days 1-5 of age. Female rats treated with raloxifene showed decreased gonadotrophin secretion, hyperprolactinaemia, advanced vaginal opening, decreased body weight, persistent presence of cornified epithelial cells in vaginal smears, anovulation, inhibition of positive feedback betweenoestradiol and LH, and infertility. Male rats showed delayed balanopreputial separation, reduced body weight and hyperprolactinaemia. All these changes resemble those obtained after neonatal administration of oestradiol benzoate, thus indicating, for the first time, that raloxifene exerts an oestrogenic action on the hypothalamic-pituitary structures controlling reproductive function in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:03:19