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Titolo:
Actions of gonadotrophins on the uterus
Autore:
Shemesh, M;
Indirizzi:
Hebrew Univ Jerusalem, Kimron Vet Inst, Dept Hormone Res, IL-50250 Bet Dagan, Israel Hebrew Univ Jerusalem Bet Dagan Israel IL-50250 -50250 Bet Dagan, Israel Hebrew Univ Jerusalem, Koret Vet Sch, IL-50250 Bet Dagan, Israel Hebrew Univ Jerusalem Bet Dagan Israel IL-50250 -50250 Bet Dagan, Israel
Titolo Testata:
REPRODUCTION
fascicolo: 6, volume: 121, anno: 2001,
pagine: 835 - 842
SICI:
1470-1626(200106)121:6<835:AOGOTU>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; LUTEINIZING-HORMONE RECEPTOR; MESSENGER-RIBONUCLEIC-ACID; BINDING-SITES; GENE-EXPRESSION; PROSTAGLANDIN PRODUCTION; LH/HCG RECEPTORS; ESTROUS-CYCLE; BOVINE CERVIX; LH-RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Shemesh, M Hebrew Univ Jerusalem, Kimron Vet Inst, Dept Hormone Res, Bet Dagan POB 12, IL-50250 Bet Dagan, Israel Hebrew Univ Jerusalem Bet Dagan POB12 Bet Dagan Israel IL-50250
Citazione:
M. Shemesh, "Actions of gonadotrophins on the uterus", REPRODUCT, 121(6), 2001, pp. 835-842

Abstract

Binding sites for LH/hCG are found in the uterus of several species, including humans. In cattle and pigs, the LH receptor, its mRNA and LH receptor protein are present in the uterus throughout the oestrous cycle, and maximum expression occurs at the luteal phase. GnRH receptor is also expressed maximally in the human endometrium at the luteal phase. LH activates both theadenylate cyclase and phospholipase C pathways and increases the concentrations of cyclooxygenase and its products. Activation of LH receptors in theendometrium is associated with PGF production. In contrast, bovine uterinevein LH receptor mRNA and LH receptor concentrations are greatest during pro-oestrus-oestrus and LH increases the production of both PGE and PCF. FSHreceptor and its mRNA are present in the bovine cervix and the concentrations are greatest at the time of the FSH peak value in the blood, indicatinga physiological role for FSH in the relaxation and opening of the cervix. The presence of gonadotrophin and releasing factor receptors with a dynamicpattern in the endometrium, myometrium, oviduct and cervix of different species provides evidence that gonadotrophins and GnRH play a substantial role as molecular autocrine-paracrine regulators of the oestrous cycle and implantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:01:47