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Titolo:
Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe far drug-related motivational states
Autore:
Fendt, M; Mucha, RF;
Indirizzi:
Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 robiol, D-72074 Tubingen, Germany Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68072 Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany D-68072 D-68072 Mannheim, Germany
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 155, anno: 2001,
pagine: 242 - 250
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRASONIC DISTRESS VOCALIZATIONS; CORTICOTROPIN-RELEASING FACTOR; PONTINE RETICULAR NUCLEUS; BRAIN REWARD PATHWAYS; ACOUSTIC STARTLE; CONDITIONED FEAR; PRECIPITATED WITHDRAWAL; LOCUS-COERULEUS; RATS; ANXIETY;
Keywords:
conditioned fear; defense reaction; deprivation; emotion; fentanyl; homeostatic; incentive; motivation; naloxone; opiate; physical dependence; startle tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Fendt, M Univ Tubingen, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 , Germany
Citazione:
M. Fendt e R.F. Mucha, "Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe far drug-related motivational states", PSYCHOPHAR, 155(3), 2001, pp. 242-250

Abstract

Rationale: Anxiety-like effects may be universal to withdrawal from drugs of abuse. The study of withdrawal would benefit from the acoustic startle response (ASR), a discrete, cross-species reflex which is increased by fear-related states. However, existing reports of opiate-related effects on baseline ASR have not validated ASR as a measure of drug-related motivation. Objective: The effects of opiate treatment and withdrawal were examined usingfear-potentiated startle, a startle test more sensitive to fear than baseline changes. Methods: Fear-conditioned rats were treated with Alzet osmoticpumps delivering 0.25 mg/kg per day fentanyl or placebo pumps. Experiment 1 examined changes before and during opiate treatment on locomotor activityand baseline, prepulse inhibition, and fear-potentiated startle. Experiment 2 examined the same responses during withdrawal precipitated after 4-7 days of treatment using IV naloxone. Results: Experiment 1 revealed an attenuated fear-potentiated startle on the first test after the start of fentanyltreatment (4 h); this was not seen on subsequent tests and suggested tolerance to this acute effect, Experiment 2 found an enhancement of fear-potentiated startle precipitated in fentanyl-treated rats after injection of 0.025 and 0.16 mg/kg naloxone; this was not seen at 1 mg/kg naloxone, even though more physical withdrawal signs were most prevalent at this dose. In neither experiment did locomotor activity, baseline ASR, or prepulse inhibitionof the ASR show any treatment effect. Conclusions: Fear-potentiated startle may provide a specific and valid measure of anxiety-like effects of drug withdrawal. Discussed were conditions needed to see this effect and the relevance of the findings for different mechanisms of withdrawal discomfort.

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Documento generato il 25/01/20 alle ore 15:36:42