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Titolo:
MUTATIONS OF THYROTROPIN RECEPTOR ISOLATED FROM THYROID AUTONOMOUS FUNCTIONING ADENOMAS CONFER TSH-INDEPENDENT GROWTH TO THYROID-CELLS
Autore:
PORCELLINI A; RUGGIANO G; PANNAIN S; CIULLO I; AMABILE G; FENZI G; AVVEDIMENTO EV;
Indirizzi:
UNIV REGGIO CALABRIA,FAC MED,DIPARTIMENTO MED SPERIMENTALE,VIA TOMMASO CAMPANELLA I-88100 CATANZARO ITALY UNIV REGGIO CALABRIA,FAC MED,DIPARTIMENTO MED SPERIMENTALE I-88100 CATANZARO ITALY FDN G PASCALE,SERV ONCOL SPERIMENTALE E,IST NAZL TUMORI I-80131 NAPLES ITALY UNIV NAPLES FEDERICO II,FAC MED,CTR ENDOCRINOL & ONCOL SPERIMENTALE I-80131 NAPLES ITALY UNIV NAPLES FEDERICO II,FAC MED,DIPARTIMENTO BIOL & PATOL MOL & CELLULARE L CALIF I-80131 NAPLES ITALY UNIV NAPLES FEDERICO II,FAC MED,DEPT ENDOCRINOL I-80131 NAPLES ITALY
Titolo Testata:
Oncogene
fascicolo: 7, volume: 15, anno: 1997,
pagine: 781 - 789
SICI:
0950-9232(1997)15:7<781:MOTRIF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATIC MUTATIONS; THYROGLOBULIN GENE; FRTL5 CELLS; EXPRESSION; ADENOSINE-3',5'-MONOPHOSPHATE; ACTIVATION; TRANSFORMATION; IDENTIFICATION; CLONING; HORMONE;
Keywords:
THYROTROPIN RECEPTOR; MUTATIONS; CAMP SIGNALING; NEOPLASM, GENETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Porcellini et al., "MUTATIONS OF THYROTROPIN RECEPTOR ISOLATED FROM THYROID AUTONOMOUS FUNCTIONING ADENOMAS CONFER TSH-INDEPENDENT GROWTH TO THYROID-CELLS", Oncogene, 15(7), 1997, pp. 781-789

Abstract

TSH receptor mutants in the VI transmembrane segment, found in thyroid autonomously functioning adeonomas, have been expressed in differentiated thyroid cells, All mutant receptors constitutively stimulated adenylyl cyclase, The biological activity, measured as cAMP production relative to the wild type receptor, was specific for each mutant in transient and stable transfection assays. Cells expressing these mutants proliferated in the absence of TSH, The rate of growth in the absence of TSH paralleled basal cAMP production for each mutant receptor, Low TSH concentrations stimulated of mutant receptor-expressing growth of the cells expressing the wild type receptor, Also, the entry in the cell cycle and the plating efficiency were markedly stimulated by the expression of the mutant receptors, These data provide a molecular link between the occurrence of TSH receptor mutations and thyroid autonomously functioning adenomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 09:55:12