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Titolo:
Semiquantitative evaluation of prevalent vertebral deformities in men and their relationship with osteoporosis: The MINOS study
Autore:
Szulc, P; Munoz, F; Marchand, F; Delmas, PD;
Indirizzi:
Hop Edouard Herriot, INSERM U403, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 NSERM U403, F-69437 Lyon, France SSMB, Montceau Les Mines, France SSMB Montceau Les Mines FranceSSMB, Montceau Les Mines, France
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 4, volume: 12, anno: 2001,
pagine: 302 - 310
SICI:
0937-941X(2001)12:4<302:SEOPVD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; X-RAY ABSORPTIOMETRY; CHINESE MEN; FRACTURES; WOMEN; POPULATION; MORPHOMETRY; DIMENSIONS; FOREARM; INDEX;
Keywords:
men; osteoporosis; vertebral fracture; vertebral morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Delmas, PD Hop Edouard Herriot, INSERM U403, Pl Arsonval, F-69437 Lyon, France Hop Edouard Herriot Pl Arsonval Lyon France F-69437 on, France
Citazione:
P. Szulc et al., "Semiquantitative evaluation of prevalent vertebral deformities in men and their relationship with osteoporosis: The MINOS study", OSTEOPOR IN, 12(4), 2001, pp. 302-310

Abstract

Epidemiologic studies have shown a high prevalence of vertebral deformities in men without a steep increase with aging, suggesting that a substantialnumber of these deformities are not related to osteoporosis. To determine which vertebral deformities are likely to be osteoporotic fractures, we compared vertebral deformities and bone mineral density (BMD) in a cohort of 786 men aged 51-85 years (the MINOS study). Normal vertebral height ratios were defined in a group of 120 healthy men aged 21-50 years. We classified vertebral deformities by using the semiquantitative method described by Genant et al., which was slightly modified at the level of thoracic kyphosis (T6-T9). At that level, grade 1 wedge deformities were defined as a 25-30% decrease in anterior vertebral height and grade 2 by a 30-40% decrease. The same cutoff of 49% was used for grade 3 for all vertebrae from T4 to L4. BMDwas measured with a Hologic 1500 device at the lumbar spine, hip and wholebody and with an Osteometer DTX 100 device at the forearm. Z-scores were calculated in 10-year age groups. The prevalence of vertebral deformities increased significantly with age. After adjustment for age and body weight, BMD did not differ between those with and without vertebral deformities. In patients having grade 2 and 3 deformities, BMD was lower than in men havingno deformities or only grade 1 deformities when adjusted for age and body weight. Using the age- and body-weight-adjusted lest of linear trend for sextiles of BMD, prevalence of grade 2 and 3 vertebral deformities increased with a decrease in BMD at all the sites of measurement. Grade 1 deformitieswere not correlated with BMD at any site. Among 126 patients who had only grade 1 vertebral deformities, 32 deformities in 30 men were confirmed as vertebral fractures according to their morphology but their BMD did not differ from the nonfractured men. These findings were confirmed when vertebral deformities were measured by the conventional morphometric method in a subgroup of 131 men. Our data suggest that a cutoff of 30% for wedge deformities from T6 to T9 and of 25% for other deformities has a high specificity anda moderate sensitivity for identifying vertebral deformities related to low BMD in men. Grade 1 deformities are often either false positive or deformities related to nonosteoporotic disease of the spine.

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Documento generato il 15/08/20 alle ore 19:49:28