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Titolo:
Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention ofp27(Kip1) in the cyclin E-cdk2 complexes
Autore:
Nahum, A; Hirsch, K; Danilenko, M; Watts, CKW; Prall, OWJ; Levy, J; Sharoni, Y;
Indirizzi:
Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Soroka Med Ctr Kupat Holim, Beer Sheva, Israel Soroka Med Ctr Kupat HolimBeer Sheva Israel Holim, Beer Sheva, Israel St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, Sydney, NSW 2010,Australia St Vincents Hosp Sydney NSW Australia 2010 am, Sydney, NSW 2010,Australia
Titolo Testata:
ONCOGENE
fascicolo: 26, volume: 20, anno: 2001,
pagine: 3428 - 3436
SICI:
0950-9232(20010607)20:26<3428:LIOCCP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
1,25-DIHYDROXYVITAMIN D-3; PROSTATE-CANCER; ALPHA-CAROTENE; BETA-CAROTENE; MCF-7 CELLS; EXPRESSION; GROWTH; DIFFERENTIATION; RETINOIDS; RISK;
Keywords:
lycopene; breast cancer; endometrial cancer; cell cycle; cyclin D1; retinoblastoma; p27(kip1);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sharoni, Y Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, POB 653, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev POB 653 Beer Sheva Israel IL-84105 srael
Citazione:
A. Nahum et al., "Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention ofp27(Kip1) in the cyclin E-cdk2 complexes", ONCOGENE, 20(26), 2001, pp. 3428-3436

Abstract

Numerous studies have demonstrated the anticancer activity of the tomato carotenoid, lycopene. However, the molecular mechanism of this action remains unknown. Lycopene inhibition of human breast and endometrial cancer cell growth is associated with inhibition of cell cycle progression at the G(1) phase. In this study we determined the lycopene-mediated changes in the cell cycle machinery. Cells synchronized in the G1 phase by serum deprivation were treated with lycopene or vehicle and restimulated with 5% serum. Lycopene treatment decreased serum-induced phosphorylation of the retinoblastomaprotein and related pocket proteins. This effect was associated with reduced cyclin-dependent kinase (cdk4 and cdk2) activities with no alterations in CDK protein levels. Lycopene caused a decrease in cyclin D1 and D3 levelswhereas cyclin E levels did not change. The CDK inhibitor p21(Cip1/Waf1) abundance was reduced while p27(Kip1) levels were unaltered in comparison tocontrol cells. Serum stimulation of control cells resulted in reduction inthe p27 content in the cyclin E-cdk2 complex and its accumulation in the cyclin D1-cdk4 complex. This change in distribution was largely prevented bylycopene treatment. These results suggest that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E-cdk2, thus leading to inhibition of G(1) CDK activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:24:25