Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
Autore:
Lara-Pezzi, E; Roche, S; Andrisani, OM; Sanchez-Madrid, F; Lopez-Cabrera, M;
Indirizzi:
Hosp Univ Princesa, Unidad Biol Mol, Madrid 28006, Spain Hosp Univ Princesa Madrid Spain 28006 idad Biol Mol, Madrid 28006, Spain Hosp Univ Princesa, Serv Inmunol, Madrid 28006, Spain Hosp Univ Princesa Madrid Spain 28006 Serv Inmunol, Madrid 28006, Spain Ctr Rech Biochem Macromol, CNRS, UPR 1086, F-34293 Montpellier, France CtrRech Biochem Macromol Montpellier France F-34293 Montpellier, France Purdue Univ, Dept Basic Med Sci, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 c Med Sci, W Lafayette, IN 47907 USA
Titolo Testata:
ONCOGENE
fascicolo: 26, volume: 20, anno: 2001,
pagine: 3323 - 3331
SICI:
0950-9232(20010607)20:26<3323:THBVHP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEPATOCELLULAR CARCINOMAS; E-CADHERIN; X-PROTEIN; TRANSGENIC MICE; BETA-CATENIN; CELL-ADHESION; TYROSINE KINASES; GENE-EXPRESSION; LIVER-CANCER; ACTIVATION;
Keywords:
cadherin; catenin; HCC; metastasis; tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Lopez-Cabrera, M Hosp Univ Princesa, Unidad Biol Mol, Diego de Leon 62, Madrid 28006, Spain Hosp Univ Princesa Diego de Leon 62 Madrid Spain 28006 n
Citazione:
E. Lara-Pezzi et al., "The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner", ONCOGENE, 20(26), 2001, pp. 3323-3331

Abstract

Chronic hepatitis B virus infection is strongly associated with the development of hepatocellular carcinoma (HCC). Epithelial tumors are frequently characterized by loss of cadherin expression or function. Cadherin-dependentadhesion prevents the acquisition of a migratory and invasive phenotype, and loss of its function is itself enough for the progression from adenoma to carcinoma, The HBx protein of hepatitis B virus is thought to contribute to the development of the carcinoma, however, its role in the oncogenic andmetastatic processes is far from being fully understood. We report herein the ability of HBx to disrupt intercellular adhesion in three different cell lines stably transfected with an inducible HBx expression vector. The linkage between the actin cytoskeleton and cadherin complex, which is essential for its function, is disrupted in the presence of HBx, as indicated by detergent solubility and immunoprecipitation experiments, In addition, beta -catenin was tyrosine phosphorylated in HBx-expressing cells, Inhibition of the src family of tyrosine kinases resulted in the prevention of the disruption of adherens junctions. These results suggest that HBx is able to disrupt intercellular adhesion in a src-dependent manner, and provide a novel mechanism by which HBx may contribute to the development of HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:03:08