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Titolo:
Evaluation of [Tc-99m] liposomes as lymphoscintigraphic agents: comparisonwith [Tc-99m] sulfur colloid and [Tc-99m] human serum albumin
Autore:
Phillips, WT; Andrews, T; Liu, HL; Klipper, R; Landry, AJ; Blumhardt, R; Goins, B;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 ept Radiol, San Antonio, TX 78284 USA Clin Nucl Serv Inc, Corpus Christi, TX USA Clin Nucl Serv Inc Corpus Christi TX USA erv Inc, Corpus Christi, TX USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 435 - 444
SICI:
0969-8051(200105)28:4<435:EO[LAL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NODE DETECTION; DRUG-DELIVERY; LYMPH-NODES; INVIVO; BIODISTRIBUTION; INJECTION; MELANOMA; BEHAVIOR;
Keywords:
liposomes; technetium-99m; lymphoscintigraphy; HMPAO; sentinel node;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, WT Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 an Antonio, TX 78284 USA
Citazione:
W.T. Phillips et al., "Evaluation of [Tc-99m] liposomes as lymphoscintigraphic agents: comparisonwith [Tc-99m] sulfur colloid and [Tc-99m] human serum albumin", NUCL MED BI, 28(4), 2001, pp. 435-444

Abstract

This study investigates the use of [Tc-99m] liposomes for the detection ofsentinel lymph nodes. A variety of [Tc-99m] liposome formulations were compared with common lymphoscintigraphic agents including [Tc-99m] regular-sulfur colloid (SC), [Tc-99m] 0.22 mu -filtered-SC, [Tc-99m] reduced heating time 0.22 mu -filtered-SC, and [Tc-99m] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [Tc-99m] regular SC demonstrated good migration from the injection site. Agents were retained in thepopliteal node at 24 hours to varying degrees as follows: both [Tc-99m] filtered SC preparations > [Tc-99m] regular SC > [Tc-99m] liposomes > [Tc-99m] HSA. [Tc-99m] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:45:56