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Titolo:
Synthesis, purification and biodistribution of (205)-Bi-DOTMP, visualizingbone deposition patterns with autoradiography
Autore:
Hassfjell, S; Ingebrigtsen, K; Bruland, OS;
Indirizzi:
Univ Oslo, Dept Chem, Nucl Chem Sect, N-0315 Oslo, Norway Univ Oslo OsloNorway N-0315 t Chem, Nucl Chem Sect, N-0315 Oslo, Norway Norwegian Sch Vet Sci, Dept Pharmacol Microbiol & Food Hyg, N-0033 Oslo, Norway Norwegian Sch Vet Sci Oslo Norway N-0033 & Food Hyg, N-0033 Oslo, Norway Norwegian Radium Hosp, Dept Oncol, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 Dept Oncol, N-0310 Oslo, Norway
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 425 - 433
SICI:
0969-8051(200105)28:4<425:SPABO(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGETED RADIOTHERAPY; MONOCLONAL-ANTIBODY; IMPROVED GENERATOR; PAIN; TOXICITY; METASTASES; PALLIATION; CELLS; RADIOIMMUNOTHERAPY; PHARMACOKINETICS;
Keywords:
Bi-205-DOTMP; autoradiography; osteosarcoma; bone metastases; Bi-212; Pb-212;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hassfjell, S Univ Oslo, Dept Chem, Nucl Chem Sect, N-0315 Oslo, Norway Univ Oslo Oslo Norway N-0315 Chem Sect, N-0315 Oslo, Norway
Citazione:
S. Hassfjell et al., "Synthesis, purification and biodistribution of (205)-Bi-DOTMP, visualizingbone deposition patterns with autoradiography", NUCL MED BI, 28(4), 2001, pp. 425-433

Abstract

A HPLC system has been developed for carrier free and rapid delivery in a physiological buffer of the alpha -particle emitting bone-seeking radiopharmaceutical Bi-212-DOTMP. Bi-205-DOTMP was synthesized and HPLC purified to mimic and visualize the deposition pattern in bony tissues of Bi-212-DOTMP by autoradiography. Inhomogeneous bone deposits were found with the highestconcentration in the bone matrix, the endosteum and in the growth zones ofyoung mice. Analysis of urine samples showed that Bi-205-DOTMP was clearedas an intact complex. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:56:19