Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of in vivo dopamine D2 receptor binding of [I-123]AIBZM and [I-123]IBZM in rat brain
Autore:
Li, HF; Gildehaus, FJ; Dresel, S; Patt, JT; Shen, MH; Zhu, T; Liu, B; Tang, ZG; Tatsch, K; Hahn, K;
Indirizzi:
Univ Munich, Dept Nucl Med, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 ept Nucl Med, D-81377 Munich, Germany Inst Interdisciplinary Isotope Res, D-04318 Leipzig, Germany Inst Interdisciplinary Isotope Res Leipzig Germany D-04318 pzig, Germany Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China Beijing Normal Univ Beijing Peoples R China 100875 0875, Peoples R China
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 4, volume: 28, anno: 2001,
pagine: 383 - 389
SICI:
0969-8051(200105)28:4<383:COIVDD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; INVITRO BINDING; RADIOLIGANDS; BENZAMIDES; SPECT; PET;
Keywords:
D2 receptor; AIBZM; IBZM; specific binding; striatum/cerebellum ratio; biodistribution in rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Li, HF Univ Munich, Dept Nucl Med, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 l Med, D-81377 Munich, Germany
Citazione:
H.F. Li et al., "Comparison of in vivo dopamine D2 receptor binding of [I-123]AIBZM and [I-123]IBZM in rat brain", NUCL MED BI, 28(4), 2001, pp. 383-389

Abstract

[I-123]AIBZM, (S)-5-[I-123]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen(TM) method. The in vivo affinity forthe D2 receptor and the biological characteristics were performed in rats. The brain uptake of [I-123]AIBZM was significantly lower, however the striatum/cerebellum ratio (2h p.i.) was higher than that of [I-123]IBZM. Because of the high affinity and its possibly lower unspecific binding compared to [I-123]IBZM, [I-123]AIBZM may be a potential imaging agent for the D2 dopamine receptor, (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:45:42