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Titolo:
Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion
Autore:
Miller, BA; Perez, RS; Shah, AR; Gonzales, ER; Park, TS; Gidday, JM;
Indirizzi:
Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 t Neurosurg, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 l & Physiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA St Louis Childrens Hosp, St Louis, MO 63110 USA St Louis Childrens Hosp St Louis MO USA 63110 osp, St Louis, MO 63110 USA
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1663 - 1669
SICI:
0959-4965(20010613)12:8<1663:CPBHPI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL CA1 NEURONS; GERBIL HIPPOCAMPUS; NEONATAL RAT; TOLERANCE; BRAIN; INDUCTION; DAMAGE; EXPRESSION; STROKE; HSP70;
Keywords:
ischemic tolerance; mice; middle cerebral artery occlusion; stroke;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gidday, JM Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 , St Louis, MO 63110 USA
Citazione:
B.A. Miller et al., "Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion", NEUROREPORT, 12(8), 2001, pp. 1663-1669

Abstract

Sublethal periods of hypoxia or ischemia can induce adaptive mechanisms toprotect against subsequent lethal ischemic insults in a process known as ischemic preconditioning. In the present study, we developed a murine model of cerebral preconditioning using several common strains of adult mice. Animals were exposed to sublethal hypoxia (11% oxygen for 2 h) 48 h prior to a90 min period of transient focal middle cerebral artery occlusion, inducedby an intraluminal filament; injury was assessed 24 h later by TTC staining. Infarct volume in hypoxia-preconditioned animals was reduced 46%, 58%, and 64% in C57B1/6, 129SvEv, and Swiss-Webster ND4 mice relative to their respective untreated controls. This noninvasive murine model of ischemic tolerance should be useful for elucidating the molecular basis of this protection using transgenic and knockout mice. NeuroReport 12:1663-1669 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:52:00