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Titolo:
Galanin enhances noradrenaline-induced outward current on locus coeruleus noradrenergic neurons
Autore:
Xu, ZQD; Tong, YG; Hokfelt, T;
Indirizzi:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1779 - 1782
SICI:
0959-4965(20010613)12:8<1779:GENOCO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CERULEUS NEURONS; CEREBRAL-CORTEX; NEUROPEPTIDE-Y; RAT; INHIBITION; RECEPTORS; BRAIN; ACTIVATION; SYSTEMS; RELEASE;
Keywords:
adrenocepters; coexistence; intracellular recording; neuropeptide; slice preparation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, ZQD Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 17177 Stockholm, Sweden
Citazione:
Z.Q.D. Xu et al., "Galanin enhances noradrenaline-induced outward current on locus coeruleus noradrenergic neurons", NEUROREPORT, 12(8), 2001, pp. 1779-1782

Abstract

Interactions between galanin and noradrenaline (NA) were studied in a locus coeruleus (LC) slice preparation using intracellular recording technique. Both galanin (10-100 nM) and NA induced an outward current. Idazoxan, an alpha2-adrenoceptor antagonist, blocked the NA- but not the galanin-induced outward current, indicating that different receptors mediate these responses. Moreover, the outward current induced by NA was enhanced and prolonged by preincubation with a low concentration of galanin (0.05-0.1 nM), which had no detectable effect on the membrane current by itself. This sensitizing effect may be of physiological importance and could be caused by galanin released from dendrites and soma of galanin/NA neurons and/or from galanin afferents. Thus, besides a direct action of galanin on locus coeruleus neurons, our results also indicate an indirect, modulating effect. NeuroReport 12:1779-1782 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:02:37