Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Normal apoptosis levels in mice expressing one alpha 7 nicotinic receptor null and one L250T mutant allele
Autore:
Broide, RS; Orr-Urtreger, A; Patrick, JW;
Indirizzi:
Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Div Neurosci, Houston, TX 77030 USA Tel Aviv Sourasky Med Ctr, Genet Inst, Tel Aviv, Israel Tel Aviv Sourasky Med Ctr Tel Aviv Israel Genet Inst, Tel Aviv, Israel
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1643 - 1648
SICI:
0959-4965(20010613)12:8<1643:NALIME>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; AUTONOMIC GANGLIA; CHANNEL DOMAIN; CELL-DEATH; DEFICIENT; NEURONS; CALCIUM; CLONING; CNS;
Keywords:
acetylcholine; apoptosis; alpha-bungarotoxin; cholinergic; nicotine; somatosensory cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Patrick, JW Baylor Coll Med, Div Neurosci, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
R.S. Broide et al., "Normal apoptosis levels in mice expressing one alpha 7 nicotinic receptor null and one L250T mutant allele", NEUROREPORT, 12(8), 2001, pp. 1643-1648

Abstract

The alpha7 nicotinic receptor (nAChR) is a ligand-gated ion channel mediating cholinergic transmission throughout the nervous system. To further characterize the function of this receptor, we generated mice expressing the alpha7 L250T nAChR mutation and demonstrated that homozygous (T/T) L250T micedie within 24 h of birth and display extensive apoptosis and abnormal layering within their cortex. We now demonstrate that mice with one alpha7 nulland one L250T allele (-/T) show little apoptosis and normal development oftheir cortex yet exhibit the same lethal phenotype as T/T mice. Furthermore, L250T mice show normal levels of apoptosis in other nervous system regions expressing alpha7 nAChRs. These results suggest that apoptosis is not the cause of death for L250T neonatal mice. NeuroReport 12:1643-1648 (C) 2001Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:02:28