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Titolo:
Co-localization of 5-HT1B/1B/1F receptors and glutamate in trigeminal ganglia in rats
Autore:
Ma, QP;
Indirizzi:
Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Merck Sharp & Dohme Res Labs, Dept Pharmacol, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Harlow Essex England CM20 2QR 2QR, Essex, England
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1589 - 1591
SICI:
0959-4965(20010613)12:8<1589:CO5RAG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLION; DURAL VASODILATION; SUBSTANCE-P; SPINAL-CORD; SUMATRIPTAN; NEURONS; AGONIST; TRANSMISSION; RIZATRIPTAN; MIGRAINE;
Keywords:
5-HT1B/1D/1F; glutamate; migraine; trigeminal ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ma, QP Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Merck Sharp & Dohme Res Labs, Dept Pharmacol, Terlings Pk, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Terlings Pk Harlow Essex England CM20 2QR d
Citazione:
Q.P. Ma, "Co-localization of 5-HT1B/1B/1F receptors and glutamate in trigeminal ganglia in rats", NEUROREPORT, 12(8), 2001, pp. 1589-1591

Abstract

Anti-migraine triptan drugs are 5-HT1B/1D receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the presentstudy, we have investigated the anatomical basis for a possible modulationof glutamate release from trigeminal ganglion neurons by 5-HT1B/1D receptor agonists and by 5-HT1F receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HT1B/1D/1F receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraineaction could be the blockade of glutamate release. NeuroReport 12:1589-1591 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:42:19