Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats
Autore:
Laurido, C; Pelissier, T; Perez, H; Flores, F; Hernandez, A;
Indirizzi:
Univ Santiago Chile, Fac Chem & Biol, Dept Biol Sci, Neurobiol Lab, Santiago, Chile Univ Santiago Chile Santiago Chile Sci, Neurobiol Lab, Santiago, Chile Univ Chile, Fac Med, Inst Biomed Sci, Santiago, Chile Univ Chile Santiago Chile le, Fac Med, Inst Biomed Sci, Santiago, Chile Univ Chile, Inst Nutr & Food Technol, Lab Hormones & Receptors, Santiago, Chile Univ Chile Santiago Chile ol, Lab Hormones & Receptors, Santiago, Chile
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 12, anno: 2001,
pagine: 1551 - 1554
SICI:
0959-4965(20010613)12:8<1551:EOKOSC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; DORSAL HORN; NMDA RECEPTOR; WIND-UP; REFLEX; PAIN; NEURONS; SENSITIZATION; HYPERALGESIA; INFLAMMATION;
Keywords:
C-fiber reflex; ketamine; NMDA receptors; pain; rats; wind-up;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Laurido, C Univ Santiago Chile, Fac Chem & Biol, Dept Biol Sci, Neurobiol Lab, POB 40Correo 33, Santiago, Chile Univ Santiago Chile POB 40 Correo 33 Santiago Chile go, Chile
Citazione:
C. Laurido et al., "Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats", NEUROREPORT, 12(8), 2001, pp. 1551-1554

Abstract

The effects of systemically and intrathecally administered ketamine on spinal wind-up of normal and monoarthritic rats were studied by using C-fiber reflex responses evoked by repetitive (0.6 Hz) electric stimulation. Both systemic and intrathecal ketamine induced dose-dependent depression of wind-up activity in normal rats, as revealed by the dose-related inhibitory effects of the drug. At the same intraperitoneal doses, ketamine produced a greater inhibitory effect on windup activity of monoarthritic rats, compared to normal animals. The intrathecal administration of ketamine also produced wind-up inhibition,the efficacy being higher in the monoarthritic rats. Results indicate that ketamine depresses spinal wind-up, specially in rats submitted to chronic pain, probably due to its antagonistic properties on dorsal horn NMDA receptors, which play a crucial role in the maintenance of chronic pain. NeuroReport 12:1551-1554 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:36:02