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Titolo:
Leptin decreases feeding and exploratory behaviour via interactions with CCK1 receptors in the rat
Autore:
Buyse, M; Bado, A; Dauge, V;
Indirizzi:
Fac Med Xavier Bichat, INSERM, U410, IFR02 Cellules Epitheliales, F-75018 Paris, France Fac Med Xavier Bichat Paris France F-75018 liales, F-75018 Paris, France UFR Sci Pharmaceut & Biol, Dept Pharmacochim Mol & Struct, INSERM, U266,UMR 8600,CNRS, F-75270 Paris 06, France UFR Sci Pharmaceut & Biol Paris France 06 CNRS, F-75270 Paris 06, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 6, volume: 40, anno: 2001,
pagine: 818 - 825
SICI:
0028-3908(200105)40:6<818:LDFAEB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; BODY-WEIGHT; OBESE GENE; OB-R; CHOLECYSTOKININ; MICE; ANXIETY; STRESS; EXPRESSION; PROTEIN;
Keywords:
leptin; CCK1 receptor; anxiety and exploratory behaviour; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Buyse, M Fac Med Xavier Bichat, INSERM, U410, IFR02 Cellules Epitheliales,16 Rue Henri Huchard, F-75018 Paris, France Fac Med Xavier Bichat 16 Rue Henri Huchard Paris France F-75018
Citazione:
M. Buyse et al., "Leptin decreases feeding and exploratory behaviour via interactions with CCK1 receptors in the rat", NEUROPHARM, 40(6), 2001, pp. 818-825

Abstract

We assessed the effects of peripheral leptin on anxiety and exploratory behaviour in the elevated plus-maze and in the four-hole box or Y-maze tests,in rats fed 80% of normal daily food intake and rats fed ad libitum. In the Y-maze test, i.p. injection of 0.4 or 1 mg/kg leptin into rationed rats significantly decreased the percentage of spontaneous alternation behaviour and increased the number of visits. In the elevated plus-maze test, rationed rats spent significantly more time in the open arms (aversive part of themaze) than did rats fed ad libitum. This difference in behaviour was abolished by injecting 0.4 mg/kg leptin. In the four-hole box test, i.p. administration of 1 mg/kg leptin significantly reduced the duration and number of hole visits in rationed and ad libitum fed rats. As with leptin inhibition of food intake, these behavioural changes caused by leptin were prevented by a CCK1 receptor antagonist (L364,718), at a dose that had no effect by itself. Finally, a 20-min stress that increased corticosterone and ACTH levels had no effect on circulating leptin levels and on the leptin content of epididymal fat tissue, stomach and brain. Thus, leptin induces hypoexploration and decreases spontaneous alternation in rats and these effects art: partly dependent on nutritional status. These results also suggest that the CCK system may be involved in the induction of these behavioural changes in rats by leptin, via the CCK1 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:45:38