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Titolo:
Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes
Autore:
Mazario, J; Gaitan, G; Herrero, JF;
Indirizzi:
Univ Alcala de Henares, Fac Med, Dept Fisiol, E-28871 Alcala De Henares, Spain Univ Alcala de Henares Alcala De Henares Spain E-28871 De Henares, Spain
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 7, volume: 40, anno: 2001,
pagine: 937 - 946
SICI:
0028-3908(200106)40:7<937:CVCIIT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORD NOCICEPTIVE REFLEXES; RAT SPINAL-CORD; SUBSTANCE-P; INTRASPINAL RELEASE; COX-2 INHIBITORS; GENE DISRUPTION; UP-REGULATION; MICE LACKING; WIND-UP; INFLAMMATION;
Keywords:
pain; wind-up; single motor unit; inflammation; non-steroidal antiinflammatory drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Herrero, JF Univ Alcala de Henares, Fac Med, Dept Fisiol, Campus Univ, E-28871 Alcala De Henares, Spain Univ Alcala de Henares Campus Univ Alcala De Henares Spain E-28871
Citazione:
J. Mazario et al., "Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes", NEUROPHARM, 40(7), 2001, pp. 937-946

Abstract

Non-steroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) enzyme and so they are effective analgesic, antiinflammatory and antipyretic drugs. The discovery of COX-2 led to the search for new NSAIDs with a selective action over this isoenzyme. The experiments performed to date have shown either more, less or no different efficacy of new COX-2 selectiveNSAIDs when compared to the non-selective inhibitors, probably because thecomparison has not been performed under similar conditions. We have therefore compared the analgesic activity of six NSAIDs with different selectivity for the COX isoenzymes. The experiments were performed using the recording of spinal cord nociceptive reflexes in anaesthetised rats and in awake mice. The non-selective COX inhibitors, such as dexketoprofen trometamol, were effective in reducing nociceptive responses both in normal and monoarthritic rats (ED50s: 0.31 and 3.97 mu mol/kg, respectively), and in mice with paw inflammation (12.5 mu mol/kg, p <0.01). The COX-1 selective inhibitor SC-58560 showed efficacy in normal rats (ED50: 0.8 mu mol/kg) and in mice with paw inflammation (15 mu mol/kg, p <0.05), but not in monoarthritic rats. The COX-2 selective inhibitors celecoxib (105 mu mol/kg) and rofecoxib (128mu mol/kg) however, were not effective in any of the groups studied. We conclude that inhibition of both COX isoenzymes is needed to achieve an effective analgesia in inflammation. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:38:18