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Titolo:
Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade
Autore:
Cartmell, J; Perry, KW; Salhoff, CR; Monn, JA; Schoepp, DD;
Indirizzi:
Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 7, volume: 40, anno: 2001,
pagine: 847 - 855
SICI:
0028-3908(200106)40:7<847:AIIMRI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; IN-VIVO MICRODIALYSIS; PREFERENTIAL ACTIVATION; DOPAMINE RELEASE; FRONTAL-CORTEX; SEROTONIN; BEHAVIORS; CLOZAPINE; STRIATUM; POTENT;
Keywords:
metabotropic glutamate receptor; dopamine; 5-HT; LY379268; clozapine; risperidone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schoepp, DD Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA EliLilly & Co Indianapolis IN USA 46285 apolis, IN 46285 USA
Citazione:
J. Cartmell et al., "Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade", NEUROPHARM, 40(7), 2001, pp. 847-855

Abstract

Our recent work (Cartmell et al., Journal of Neurochemistry, 75 (2000) 1147-1154) demonstrated that systemic injection of the potent, selective mGlu2/3 receptor agonist, LY379268, acutely increased extracellular levels of dopamine, its metabolites DOPAC and HVA, and the 5-HT metabolite, 5-HIAA, in rat medial prefrontal cortex (mPFC). Here, we compared the acute effects ofLY379268 with those of clozapine and risperidone (atypical antipsychotics)on extracellular levels of both dopamine and 5-HT in the mPFC of freely-moving rats. Uptake blockers were included to minimize metabolism of monoamines near the probe area. One hour after injection, LY379268 (10 mg/kg s.c.),clozapine (10 mg/kg s.c.) or risperidone (1 mg/kg s.c.) maximally increased dopamine by 224, 257 and 234% of basal levels. These effects were followed by maximal increases in DOPAC and HVA levels 2 to 3.5 hours after administration. LY379268, at 3 and 10 mg/kg s.c., and risperidone (1 mg/kg s.c.) also increased dialysate 5-HT to 169, 179 and 140% of basal levels and 5-HIAA to 144, 154 and 121% of basal levels, respectively. These neurochemical changes in the mPFC could not be mimicked when LY379268 (3 or 30 muM) was administered locally via the microdialysis probe. These data demonstrate thatincreases in extracellular monoamines in the rat prefrontal cortex evoked acutely by the mGlu2/3 agonist, LY379268, are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 29/09/20 alle ore 06:34:58