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Titolo:
Selective involvement of mGlu1 receptors in corticostriatal LTD
Autore:
Gubellini, P; Saulle, E; Centonze, D; Bonsi, P; Pisani, A; Bernardi, G; Conquet, F; Calabresi, P;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy IRCCS, Fdn Santa Lucia, Rome, Italy IRCCS Rome ItalyIRCCS, Fdn Santa Lucia, Rome, Italy CNR, Ist Neurosci & Med Mol, Rome, Italy CNR Rome ItalyCNR, Ist Neurosci & Med Mol, Rome, Italy IBCM, Galxo Wellcome Expt Res, Lausanne, Switzerland IBCM Lausanne Switzerland alxo Wellcome Expt Res, Lausanne, Switzerland
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 7, volume: 40, anno: 2001,
pagine: 839 - 846
SICI:
0028-3908(200106)40:7<839:SIOMRI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; METABOTROPIC GLUTAMATE RECEPTORS; HIPPOCAMPAL PYRAMIDAL CELLS; RAT STRIATAL NEURONS; DHPG-INDUCED LTD; GYRUS IN-VITRO; SYNAPTIC PLASTICITY; DENTATE GYRUS; CA1 REGION; ACTIVATION;
Keywords:
synaptic plasticity; electrophysiology; glutamate; transgenic mice; group I metabotropic glutamate receptors; AIDA; LY 367385;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Calabresi, P Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata135 Rome Italy I-00133
Citazione:
P. Gubellini et al., "Selective involvement of mGlu1 receptors in corticostriatal LTD", NEUROPHARM, 40(7), 2001, pp. 839-846

Abstract

Although metabotropic glutamate receptors (mGluRs) have been proposed to play a role in corticostriatal long-term depression (LTD), the specific receptor subtype required for this form of synaptic plasticity has not been characterized yet. Thus, we utilized a corticostriatal brain slice preparationand intracellular recordings from striatal spiny neurons to address this issue. We observed that both AIDA (100 muM) and LY 367385 (30 muM), two blockers of mGluR1s, were able to fully prevent the induction of this form of synaptic plasticity, whereas MPEP (30 muM), a selective antagonist of the mGluR5 subtype, did not significantly affect the amplitude and time-course ofcorticostriatal LTD. Both AIDA and LY 367385 were ineffective on LTD when applied after its induction. The critical role of mGluR1s in the formation of corticostriatal LTD was confirmed in experiments performed on mice lacking mGluR1s. In these mice, in fact, a significant reduction of the LTD amplitude was observed in comparison to the normal LTD measured in their wild-type counterparts. We found that neither acute pharmacological blockade of mGluR1s nor the genetic disruption of these receptors affected the presynaptic modulation of corticostriatal excitatory postsynapic potentials (EPSPs) exerted by DCG-IV and L-SOP, selective agonists of group II and III mGluRs,respectively. Our data show that the induction of corticostriatal LTD requires the activation of mGluR1 but not mGluR5. mGluR1-mediated control of this form of synaptic plasticity may play a role in the modulatory effect exerted by mGluRsin the basal ganglia-related motor activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Documento generato il 22/09/20 alle ore 13:46:09