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Titolo:
Neuromodulation of Na+ channels: An unexpected form of cellular plasticity
Autore:
Cantrell, AR; Catterall, WA;
Indirizzi:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USAUniv Tennessee Memphis TN USA 38163 at & Neurobiol, Memphis, TN 38163 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 6, volume: 2, anno: 2001,
pagine: 397 - 407
SICI:
1471-0048(200106)2:6<397:NONCAU>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; BRAIN SODIUM-CHANNELS; MUSCARINIC ACETYLCHOLINE-RECEPTOR; CAMP-DEPENDENT PHOSPHORYLATION; RAT HIPPOCAMPAL-NEURONS; CA1 PYRAMIDAL CELLS; ALPHA-SUBUNIT; DOPAMINE-RECEPTORS; XENOPUS-OOCYTES; SELECTIVE PHOSPHORYLATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Catterall, WA Univ Washington, Dept Pharmacol, Box 357280, Seattle, WA 98195 USA Univ Washington Box 357280 Seattle WA USA 98195 WA 98195 USA
Citazione:
A.R. Cantrell e W.A. Catterall, "Neuromodulation of Na+ channels: An unexpected form of cellular plasticity", NAT REV NEU, 2(6), 2001, pp. 397-407

Abstract

Voltage-gated Na+ channels set the threshold for action potential generation and are therefore good candidates to mediate forms of plasticity that affect the entire neuronal output. Although early studies led to the idea that Na+ channels were not subject to modulation, we now know that Na+ channelfunction is affected by phosphorylation. Furthermore, Na+ channel modulation is implicated in the control of input-output relationships in several types of neuron and seems to be involved in phenomena as varied as cocaine withdrawal, hyperalgesia and light adaptation. Here we review the available evidence for the regulation of Na+ channels by phosphorylation, its molecular mechanism, and the possible ways in which it affects neuronal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:32:55