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Titolo:
Mechanisms of transcriptional memory
Autore:
Francis, NJ; Kingston, RE;
Indirizzi:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Mol Biol, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 6, volume: 2, anno: 2001,
pagine: 409 - 421
SICI:
1471-0072(200106)2:6<409:MOTM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCOMB-GROUP PROTEINS; CHROMATIN REMODELING COMPLEX; DROSOPHILA BITHORAX COMPLEX; CHROMOSOME-BINDING-SITES; HOMEOTIC GENE-EXPRESSION; TRITHORAX GROUP PROTEINS; SWI-SNF COMPLEX; RESPONSE ELEMENT; TARGET GENES; IN-VIVO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Kingston, RE Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ton, MA 02114 USA
Citazione:
N.J. Francis e R.E. Kingston, "Mechanisms of transcriptional memory", NAT REV MOL, 2(6), 2001, pp. 409-421

Abstract

How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:49:11