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Titolo:
Effects of pergolide on sensorimotor gating of the startle reflex in rats
Autore:
Swerdlow, NR; Platten, A; Shoemaker, J; Pitcher, L; Auerbach, P;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 158, anno: 2001,
pagine: 230 - 240
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION DEFICITS; DOPAMINE-RECEPTOR AGONISTS; ACOUSTIC STARTLE; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; TOURETTES-SYNDROME; NUCLEUS-ACCUMBENS; D-AMPHETAMINE; TREATED RATS; APOMORPHINE;
Keywords:
dopamine; pergolide; prepulse inhibition; schizophrenia; startle reflex; Tourette syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gillman Dr La Jolla CA USA 92093 SA
Citazione:
N.R. Swerdlow et al., "Effects of pergolide on sensorimotor gating of the startle reflex in rats", PSYCHOPHAR, 158(3), 2001, pp. 230-240

Abstract

Rationale: Prepulse inhibition (PPI), a cross-species measure of sensorimotor gating, is impaired in certain neuropsychiatric disorders, including schizophrenia. This study was designed to assess the effects of the D2-familyagonist pergolide in rats, in anticipation of human studies of the dopaminergic regulation of PPI. Methods: The effects of pergolide (0.0001-0.5 mg/kg) on PPI of the acoustic startle reflex were studied in rats using a wide range of prepulse intensities [1-15 dB(A) over background] and prepulse intervals (5-100 ms, onset to onset). Studies also examined the effects of theD2 antagonist haloperidol on pergolide-induced changes in PPI. Results: Pergolide exhibited dose- and stimulus-dependent effects on PPI. Pergolide increased PPI when startle stimuli were preceded by weak prepulses [1-5 dB(A)over background] at the longest prepulse interval (100 ms), or intense prepulses [15 dB(A) over background] at short prepulse intervals (5-20 ms). Pergolide (0.5 mg/kg) also decreased PPI elicited by intense prepulses at long intervals (60-100 ms). Both PPI-enhancing and PPI-disruptive effects of pergolide were reversed by the D2 antagonist haloperidol. Conclusions: Theseeffects of pergolide suggest that D2 substrates mediate opposing, influences on PPI under different stimulus conditions. The dopaminergic regulation of sensorimotor gating appears to interact with stimulus characteristics such as relative intensity and temporal separation, allowing for dynamic shifts in both the quantity and quality of "gated" information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:04:30