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Titolo:
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals athigh risk for liver cancer
Autore:
Egner, PA; Wang, JB; Zhu, YR; Zhang, BC; Wu, Y; Zhang, QN; Qian, GS; Kuang, SY; Gange, SJ; Jacobson, LP; Helzlsouer, KJ; Bailey, GS; Groopman, JD; Kensler, TW;
Indirizzi:
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Bloomberg Sch Publ Hlth Baltimore MD USA 21205 MD 21205 USA Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205USA Johns Hopkins Bloomberg Sch Publ Hlth Baltimore MD USA 21205 MD 21205USA Qidong Liver Canc Inst, Qidong 226200, Jiangsu, Peoples R China Qidong Liver Canc Inst Qidong Jiangsu Peoples R China 226200 ples R China Oregon State Univ, Dept Food Sci, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 ood Sci, Corvallis, OR 97331 USA Shanghai Canc Inst, Shanghai 200032, Peoples R China Shanghai Canc Inst Shanghai Peoples R China 200032 0032, Peoples R China
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 25, volume: 98, anno: 2001,
pagine: 14601 - 14606
SICI:
0027-8424(200112)98:25<14601:CIRAAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPUBLIC-OF-CHINA; HEPATOCELLULAR-CARCINOMA; CHEMOPREVENTION TRIAL; NATURAL CHLOROPHYLLS; RAINBOW-TROUT; B-1; OLTIPRAZ; IDENTIFICATION; MECHANISMS; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kensler, TW Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci,615 N WolfeSt, Baltimore, MD 21205 USA Johns Hopkins Bloomberg Sch Publ Hlth 615 N Wolfe St Baltimore MD USA 21205
Citazione:
P.A. Egner et al., "Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals athigh risk for liver cancer", P NAS US, 98(25), 2001, pp. 14601-14606

Abstract

Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part from consumption of foods contaminated with aflatoxins. Chlorophyllin, a mixture of semisynthetic, water-soluble derivatives of chlorophyll that is used as a food colorant and over-the-counter medicine, has been shown to be an effective inhibitor of Elf latoxin hepatocarcinogenesis in animal models by blocking carcinogen bioavailability. In a randomized, double-blind, placebo-controlled chemopreventiontrial, we tested whether chlorophyllin could alter the disposition of aflatoxin. One hundred and eighty healthy adults from Qidong were randomly assigned to ingest 100 mg of chlorophyllin or a placebo three times a day for 4months. The primary endpoint was modulation of levels of aflatoxin-N-7-guanine adducts in urine samples collected 3 months into the intervention measured by using sequential immunoaffinity chromatography and liquid chromatography-electrospray mass spectrometry. This aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose of aflatoxin, and elevated levels are associated with increased risk of liver cancer. Adherence to the study protocol was outstanding, and no adverse events werereported. Aflatoxin-N-7-guanine could be detected in 105 of 169 available samples. Chlorophyllin consumption at each meal led to an overall 55% reduction (P = 0.036) in median urinary levels of this aflatoxin biomarker compared with those taking placebo. Thus, prophylactic interventions with chlorophyllin or supplementation of diets with foods rich in chlorophylls may represent practical means to prevent the development of hepatocellular carcinoma or other environmentally induced cancers.

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Documento generato il 26/09/20 alle ore 02:33:17