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Titolo:
Spirocyclic restriction of nucleosides. Synthesis of the first exemplary syn-1-oxaspiro[4.4]nonanyl member
Autore:
Paquette, LA; Bibart, RT; Seekamp, CK; Kahane, AL;
Indirizzi:
Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 s Chem Labs, Columbus, OH 43210 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 25, volume: 3, anno: 2001,
pagine: 4039 - 4041
SICI:
1523-7060(200112)3:25<4039:SRONSO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEIC-ACID ANALOGS; BASE-PAIRING PROPERTIES; BACKBONE BICYCLO-DNA; CONSTRAINT CONFORMATIONAL FLEXIBILITY; CARBOCYCLIC NUCLEOSIDES; REVERSE-TRANSCRIPTASE; ADENOSINE-DEAMINASE; CRYSTAL-STRUCTURE; TRICYCLO-DNA; OLIGONUCLEOTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Paquette, LA Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA OhioState Univ Columbus OH USA 43210 Columbus, OH 43210 USA
Citazione:
L.A. Paquette et al., "Spirocyclic restriction of nucleosides. Synthesis of the first exemplary syn-1-oxaspiro[4.4]nonanyl member", ORG LETT, 3(25), 2001, pp. 4039-4041

Abstract

[GRAPHICS]The potential benefits associated with the spirocyclic restriction of nucleosides are summarized. Following exploration of pi -allylpalladium route to 5'-alpha- or syn-dideoxy examples, we evaluated MOM protection of the 5'-hydroxyl as being suited to the synthesis of the first member of this new class of nucleoside mimic.

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Documento generato il 23/01/20 alle ore 04:19:07