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Titolo:
Corneal toxicity of xylazine and clonidine, in combination with ketamine, in the rat
Autore:
Tita, B; Leone, MG; Casini, ML; Corubolo, C; Bordi, F; Guidolin, G; Fumagalli, E; Romanelli, L; Mattioli, F; Feher, J; Saso, L;
Indirizzi:
Univ Roma La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 en Physiol, I-00185 Rome, Italy Fidia Res Labs, Padua, Italy Fidia Res Labs Padua ItalyFidia Res Labs, Padua, Italy
Titolo Testata:
OPHTHALMIC RESEARCH
fascicolo: 6, volume: 33, anno: 2001,
pagine: 345 - 352
SICI:
0030-3747(200111/12)33:6<345:CTOXAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAOCULAR-PRESSURE; VETERINARY-MEDICINE; ANESTHESIA; YOHIMBINE; TRANSPORT; ANTAGONISM; SEGMENT; EYE;
Keywords:
aqueous humor; clonidine; corneal opacification; corneal edema; corneal permeability; glucose; ketamine; xylazine; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Saso, L Univ Roma La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol, Piazzale Aldo Moro 5, I-00185 Rome, Italy Univ Roma La Sapienza Piazzale Aldo Moro 5 Rome Italy I-00185 aly
Citazione:
B. Tita et al., "Corneal toxicity of xylazine and clonidine, in combination with ketamine, in the rat", OPHTHAL RES, 33(6), 2001, pp. 345-352

Abstract

Purpose: To compare the corneal toxicity of xylazine (XYL)/ketamine (KET) with that of clonidine (CLO)/KET in the rat, in the presence or not of the alpha (2)-adrenergic antagonist yohimbine (YOH). Methods: XYL (10 mg/kg) and CLO (0.15 mg/kg) were administered subcutaneously in the rat in combination with KET (50 mg/kg), in the presence or not of YOH (2 mg/kg). Results: The corneas immediately lost transparency and luster, but recovered within 120 min. By both light and electron microscopy, a marked stromal edema and alterations of all layers were observed. In addition, XYL/KET altered the permeability of the cornea as indicated by the augmented levels of C-14-indomethacin, topically administered 30 min after the anesthetic combination. Conclusions: The mechanism of the corneal toxicity of XYL and CLO in the rat is unclear but we speculate that: (a) proptosis and inhibition of normal blinking did not play a major role because topical application of hyaluronic acid did not protect against it; corneal decompensation, edema and opacification could be due to (b) osmotic or (c) mechanical endothelial stress: thefirst resulting from the sudden increase of the glucose concentration in the aqueous humor due to the well-known inhibition of insulin release by alpha (2)-adrenergic agonists, and the second from the acute elevation of intraocular pressure caused by these alpha (2)-adrenergic mydriatics in the rat; (d) addition, XYL and CLO could act by directly interacting with local alpha (2)- or, possibly, alpha (1)-adrenergic receptors, whose function is still not clear but probably essential for corneal homeostasis. Copyright (C)2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:40:37