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Titolo:
Polyunsaturated fatty acids and cognitive functions
Autore:
Chalon, S;
Indirizzi:
Univ Tours, UFR Sci Pharmaceut, Lab Biophys Med & Pharmaceut, INSERM,U316,F-37200 Tours, France Univ Tours Tours France F-37200 aceut, INSERM,U316,F-37200 Tours, France
Titolo Testata:
OCL-OLEAGINEUX CORPS GRAS LIPIDES
fascicolo: 4, volume: 8, anno: 2001,
pagine: 317 - 320
SICI:
1258-8210(200107/08)8:4<317:PFAACF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
FRE
Soggetto:
ALPHA-LINOLENIC ACID; RAT FRONTAL-CORTEX; LEARNING-ABILITY; SEROTONINERGIC NEUROTRANSMISSION; BEHAVIORAL-DEVELOPMENT; LIPID COMPOSITIONS; SOYBEAN OIL; BRAIN; DEFICIENCY; DIET;
Keywords:
behaviour; DHA; monoaminergic neurotransmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Chalon, S Univ Tours, UFR Sci Pharmaceut, Lab Biophys Med & Pharmaceut, INSERM,U316,31 Ave Monge, F-37200 Tours, France Univ Tours 31 Ave Monge Tours France F-37200 7200 Tours, France
Citazione:
S. Chalon, "Polyunsaturated fatty acids and cognitive functions", OCL-OL CORP, 8(4), 2001, pp. 317-320

Abstract

The role of essential fatty acids in cerebral function can be approached using animal models receiving controlled dietary supply of n-3 and n-6 PUFAs. Several findings showed that a n-3 PUFA deficiency reduced the learning abilities whereas DHA supply improved these functions. However, it is difficult to distinguish between direct effects on learning and effects on performance factors such as visual competence, motivation, attention, or sensory threshold. The mechanisms involved in these effects are still portly unknown. PUFAs can act on cognitive functions through effects on the physical properties of cerebral membranes, with possible consequences on anchored proteins (receptors, transporters). They can also directly act on gene functions. In addition, effects of PUFAs can be mediated through a role on cell signalling, as they are eicosanoid precursors. Globally, more and more evidences are in agreement with influence of the PUFA status on neurotransmission processes, especially dopaminergic, serotoninergic and cholinergic. In humans, it is more difficult to evaluate the real impact of PUFAs on cognitive functions. However, data obtained on the mental evaluation during developmental period and relationships between PUFA status and neuropsychiatric disorders are in favour of effects of PUFAs on cerebral functions. This field ofresearch illustrates the potential role of environmental factors on the mental health.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:47:55