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Titolo:
Functional activity within brain tumors: A magnetic source imaging study
Autore:
Schiffbauer, H; Ferrari, P; Rowley, HA; Berger, MS; Roberts, TPL;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, Biomagnet Imaging Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Oulu, Oulu Clin Neursurg, Oulu, Finland Univ Oulu Oulu FinlandUniv Oulu, Oulu Clin Neursurg, Oulu, Finland
Titolo Testata:
NEUROSURGERY
fascicolo: 6, volume: 49, anno: 2001,
pagine: 1313 - 1320
SICI:
0148-396X(200112)49:6<1313:FAWBTA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY-MOTOR CORTEX; SENSORIMOTOR CORTEX; INTRAOPERATIVE STIMULATION; GUIDED NEUROSURGERY; RESECTION; MAGNETOENCEPHALOGRAPHY; GLIOMAS; SURGERY; LOCALIZATION; EXTENT;
Keywords:
brain tumors; cortex; functional imaging; magnetic source imaging; magnetoencephalography; preoperative planning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, TPL Univ Calif San Francisco, Dept Radiol, Biomagnet Imaging Lab,513 Parnassus Ave S-362,Box 0628, San Francisco, CA 94143 USA Univ Calif San Francisco 513 Parnassus Ave S-362,Box 0628 San Francisco CA USA 94143
Citazione:
H. Schiffbauer et al., "Functional activity within brain tumors: A magnetic source imaging study", NEUROSURGER, 49(6), 2001, pp. 1313-1320

Abstract

OBJECTIVE: To determine whether low-grade gliomas contain functional cortical activity more often than high-grade gliomas within radiologically defined abnormal tissue. METHODS: Patients with intra-axial cerebral lesions located in the vicinity of eloquent brain cortex preoperatively underwent magnetic source imaging. A dual 37-channel biomagnetometer was used to perform the imaging. Evokedmagnetic fields were analyzed using the single-equivalent dipole representation to ascertain the neuronal source. Stimuli included painless tactile somatosensory stimulation of fingers, toes, and lips and auditory presentation of pure sinusoidal tones. RESULTS: A retrospective analysis of 106 nonconsecutively treated patients, who had undergone preoperative magnetic source imaging between February 1996 and December 1999, revealed that 24.5% of the patients had been at riskfor neurological deficits, because functionally active tissue was located within or at the border of the tumor. Functional activity was found within the radiologically defined lesion in 18% of Grade 2 tumors, in 17% of Grade3 tumors, and in 8% of Grade 4 tumors. CONCLUSION: The results confirm that, regardless of tumor grade, intra-axial brain tumors may involve or directly border on functional cortex. The degree of involvement of functionally viable cortex appeared greater for low-grade tumors than for high-grade lesions. On the other hand, high-grade lesions were more likely to be associated with functional cortex at their margins or within peritumoral edema. To safely maximize tumor resection, preoperative functional imaging and intraoperative electrophysiological mapping of the cerebral cortex and the white matter tracts are deemed necessary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:03:33