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Titolo:
Human Nck-associated protein1 and its binding protein affect the metabolism of beta-amyloid precursor protein with Swedish mutation
Autore:
Yamamoto, A; Behl, C;
Indirizzi:
Max Planck Inst Psychiat, Independent Res Grp Neurodegenerat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 316, anno: 2001,
pagine: 50 - 54
SICI:
0304-3940(200112)316:1<50:HNPAIB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-SECRETASE ACTIVITY; ALZHEIMERS-DISEASE; ALPHA-SECRETASE; PEPTIDE; ENDOPROTEOLYSIS; SEPARATION; CLEAVAGE; DOMAIN; CELLS;
Keywords:
Alzheimer's disease; beta-amyloid precursor protein; amyloid beta; Nck-associated protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Behl, C Max Planck Inst Psychiat, Independent Res Grp Neurodegenerat, Kraepelinstr2-10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr2-10 Munich Germany D-80804
Citazione:
A. Yamamoto e C. Behl, "Human Nck-associated protein1 and its binding protein affect the metabolism of beta-amyloid precursor protein with Swedish mutation", NEUROSCI L, 316(1), 2001, pp. 50-54

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system, and beta -amyloid precursor protein (beta APP) plays a pivotal role in AD pathology. We previously reported that the suppression of human Nck-associated protein 1 (Nap1) whose expression was down-regulated in sporadic AD led to apoptosis in human neuroblastoma cells, and also its binding protein, hNap1BP was identified. Here, we examined whether these molecules were involved in the regulation of beta APP metabolism. Human Nap1 and hNap1BP were found not to effect the amount of intracellular beta APP but induced sAPP alpha secretion. Interestingly, they didn't reduce but slightly increased the extracellular level of A beta. Furthermore, neither human Nap1 nor hNap1BP influenced the ratio of A beta 42/43 to total A beta. Taken together, human Nap1 and hNap1BP may play a role in regulation of beta -secretase activity in the processing of beta APP. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 04/04/20 alle ore 08:50:12