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Titolo:
Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes
Autore:
Cavedini, P; Riboldi, G; DAnnucci, A; Belotti, P; Cisima, M; Bellodi, L;
Indirizzi:
Vita Salute San Raffaele Univ, San Raffaele Sci Inst, Dept Neuropsychiat Sci, I-20127 Milan, Italy Vita Salute San Raffaele Univ Milan Italy I-20127 , I-20127 Milan, Italy
Titolo Testata:
NEUROPSYCHOLOGIA
fascicolo: 2, volume: 40, anno: 2002,
pagine: 205 - 211
SICI:
0028-3932(2002)40:2<205:DHIODV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE METABOLIC RATES; FRONTAL-LOBE DYSFUNCTION; ORGANIZATION; DEPRESSION; MEMORY; DAMAGE; SCALE;
Keywords:
prefrontal cortex; decision-making; gambling task; obsessive-compulsive disorder; predictors; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bellodi, L Vita Salute San Raffaele Univ, San Raffaele Sci Inst, Dept Neuropsychiat Sci, 20 Via Stamira Ancona, I-20127 Milan, Italy Vita Salute San Raffaele Univ 20 Via Stamira Ancona Milan Italy I-20127
Citazione:
P. Cavedini et al., "Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes", NEUROPSYCHO, 40(2), 2002, pp. 205-211

Abstract

Certain clinical aspects of patients with Obsessive-Compulsive Disorder (OCD) appear similar to those of patients with damage to the ventromedial sector of the prefrontal cortex. The hypothesis for the involvement of the frontal region in OCD is also supported by neuropsychological findings. Building on this evidence, we assessed the performance of a group of 34 OCD patients on a measure indexing with orbitofrontal cortex functioning and compared it with the performance of two other subject groups, one consisting of 34healthy control subjects and the other 16 patients with panic disorder. All study subjects performed a neuropsychological task, which is sensitive tofrontal lobe dysfunction and simulating real-life decision-making. Significant differences were found between the neuropsychological profiles of the OCD and of other groups, pointing to a possible specificity of decision-making deficit in OCD. Comparison of the performance of the OCD patients grouped according to response to antiobsessive drug treatment showed that poor neuropsychological task performance predicted poor outcome of pharmacological treatment. Task behavior did not correlate with severity of illness or demographic characteristics of the subjects. Results support the role of the ventromedial prefrontal cortex in OCD. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:40:52