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Titolo:
Effects of estrogen replacement therapy on human brain aging: An in vivo H-1 MRS study
Autore:
Robertson, DMW; van Amelsvoort, T; Daly, E; Simmons, A; Whitehead, M; Morris, RG; Murphy, KC; Murphy, DGM;
Indirizzi:
Maudsley Hosp & Inst Psychiat, Dept Neuroimaging, London SE5 8AZ, England Maudsley Hosp & Inst Psychiat London England SE5 8AZ on SE5 8AZ, England Harvard Univ, Sch Med, Dept Obstet & Gynaecol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 t & Gynaecol, Cambridge, MA 02138 USA Univ London Kings Coll Hosp, Sch Med, Dept Obstet & Gynaecol, London, England Univ London Kings Coll Hosp London England & Gynaecol, London, England Inst Psychiat, Neuropsychol Unit, London, England Inst Psychiat London England ychiat, Neuropsychol Unit, London, England Inst Psychiat, Dept Neurol, London SE5 8AF, England Inst Psychiat LondonEngland SE5 8AF ept Neurol, London SE5 8AF, England Inst Psychiat, Dept Med Psychol, London, England Inst Psychiat London England sychiat, Dept Med Psychol, London, England
Titolo Testata:
NEUROLOGY
fascicolo: 11, volume: 57, anno: 2001,
pagine: 2114 - 2117
SICI:
0028-3878(200112)57:11<2114:EOERTO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; CHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, DMW Inst Psychiat, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF gland
Citazione:
D.M.W. Robertson et al., "Effects of estrogen replacement therapy on human brain aging: An in vivo H-1 MRS study", NEUROLOGY, 57(11), 2001, pp. 2114-2117

Abstract

Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naive postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflectsincreased neuronal/glial membrane turnover. Thus, ERT's "neuroprotective" effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 07:26:58