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Titolo:
Mapping transient, randomly occurring neuropsychological events using independent component analysis
Autore:
Gu, H; Engelien, W; Feng, HH; Silbersweig, DA; Stern, E; Yang, YH;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 14, anno: 2001,
pagine: 1432 - 1443
SICI:
1053-8119(200112)14:6<1432:MTRONE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FMRI TIME-SERIES; POSITRON EMISSION TOMOGRAPHY; FUNCTIONAL MRI; HUMAN BRAIN; DATA SETS; SENSORY STIMULATION; BLIND SEPARATION; SINGLE SUBJECTS; ACTIVATION; CONNECTIVITY;
Keywords:
fMRI; independent component analysis; randomly occurring events; data-driven analysis; computer simulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, YH Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, 525 E68th St,Box 140,Rm F-1306, New York, NY 10021 USA Cornell Univ 525E 68th St,Box 140,Rm F-1306 New York NY USA 10021
Citazione:
H. Gu et al., "Mapping transient, randomly occurring neuropsychological events using independent component analysis", NEUROIMAGE, 14(6), 2001, pp. 1432-1443

Abstract

The feasibility of mapping transient, randomly occurring neuropsychological events using independent component analysis (ICA) was evaluated in an auditory sentence-monitoring fMRI experiment, in which prerecorded short sentences of random content were presented in varying temporal patterns. The efficacy of ICA on fMRI data with such temporal characteristics was assessed by a series of simulation studies, as well as by human activation studies. The effects of contrast-to-noise ratio level, spatially varied hemodynamic response within a brain region, time lags of the responses among brain regions, and different simulated. activation locations on the ICA were investigated in the simulations. Component maps obtained from the auditory sentence-monitoring experiments in each subject using ICA showed distinct activationin bilateral auditory and language cortices, as well as in superior sensorimotor cortices, consistent with previous PET studies. The associated time courses in the activated brain regions matched well to the timing of the sentence presentation, as evidenced by the recorded button-press response signals. Methods for ICA component ordering that may rank highly the components of primary interest in such experiments were developed. The simulation results characterized the performance of ICA under various conditions and mayprovide useful information for experimental design and data interpretation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:25:58