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Titolo:
Local brain functional activity following early deprivation: A study of postinstitutionalized Romanian orphans
Autore:
Chugani, HT; Behen, ME; Muzik, O; Juhasz, C; Nagy, F; Chugani, DC;
Indirizzi:
Wayne State Univ, Sch Med, Detroit Med Ctr, Childrens Hosp,Dept Pediat, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 ,Dept Pediat, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Detroit Med Ctr, Childrens Hosp,Dept Neurol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 ,Dept Neurol, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Detroit Med Ctr, Childrens Hosp,Dept Radiol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 ,Dept Radiol, Detroit, MI 48201 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 14, anno: 2001,
pagine: 1290 - 1301
SICI:
1053-8119(200112)14:6<1290:LBFAFE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORTICOTROPIN-RELEASING FACTOR; CEREBRAL GLUCOSE-UTILIZATION; ADVERSE EXPERIENCES; SOCIAL DEPRIVATION; MACAQUE MONKEY; RHESUS-MONKEYS; CORTEX; STRESS; RESPONSES;
Keywords:
positron emission tomography; 2-deoxy2-[(18)]fluoro-D-glucose; hypometabolism; children; maternal deprivation; behavior; limbic system; hippocampus; amygdala; prefrontal cortex; stress; statistical parametric mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Chugani, HT Wayne State Univ, Sch Med, Detroit Med Ctr, Childrens Hosp,Dept Pediat, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 , Detroit, MI 48201 USA
Citazione:
H.T. Chugani et al., "Local brain functional activity following early deprivation: A study of postinstitutionalized Romanian orphans", NEUROIMAGE, 14(6), 2001, pp. 1290-1301

Abstract

Early global deprivation of institutionalized children may result in persistent specific cognitive and behavioral deficits. In order to examine braindysfunction underlying these deficits, we have applied positron emission tomography using 2-deoxy-2-[F-18]fluoro-D-glucose in 10 children (6 males, 4females, mean age 8.8 years) adopted from Romanian orphanages. Using statistical parametric mapping (SPM), the pattern of brain glucose metabolism inthe orphans was compared to the patterns obtained from two control groups:(i) a group of 17 normal adults (9 males, 8 females, mean age 27.6 years) and (ii) a group of 7 children (5 males and 2 females, mean age 10.7 years)with medically refractory focal epilepsy, but normal glucose metabolism pattern in the contralateral hemisphere. Consistent with previous studies of children adopted from Romanian orphanages, neuropsychological assessment ofRomanian orphans in the present study showed mild neurocognitive impairment, impulsivity, and attention and social deficits. Comparing the normalizedglucose metabolic rates to those of normal adults, the Romanian orphans showed significantly decreased metabolism bilaterally in the orbital frontal gyrus, the infralimbic prefrontal cortex, the medial temporal structures (amygdala and head of hippocampus), the lateral temporal cortex, and the brain stem. These findings were confirmed using a region-of-interest approach. SPM analysis showed significantly decreased glucose metabolism in the same brain regions comparing the orphans to the nonepileptic hemisphere of the childhood epilepsy controls. Dysfunction of these brain regions may result from the stress of early global deprivation and may be involved in the long-term cognitive and behavioral deficits displayed by some Romanian orphans. (C) 2001 Academic Press.

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Documento generato il 02/04/20 alle ore 00:12:02