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Titolo:
The role of the hippocampus in trace conditioning: Temporal discontinuity or task difficulty?
Autore:
Beylin, AV; Gandhi, CC; Wood, GE; Talk, AC; Matzel, LD; Shors, TJ;
Indirizzi:
Rutgers State Univ, Dept Psychol, Ctr Collaborat Neurosci, Program Biopsychol & Behav Neurosci, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 osci, Piscataway, NJ 08854 USA Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 pt Psychol, Princeton, NJ 08544 USA Princeton Univ, Program Neurosci, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 m Neurosci, Princeton, NJ 08544 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 447 - 461
SICI:
1074-7427(200111)76:3<447:TROTHI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; MAMMALIAN BRAIN; LESIONS; ACQUISITION; MEMORY; RAT; NEUROGENESIS; RETENTION; DISRUPTS; RABBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Shors, TJ Rutgers State Univ, Dept Psychol, Ctr Collaborat Neurosci, Program Biopsychol & Behav Neurosci, 152 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 152 Frelinghuysen Rd Piscataway NJ USA 08854
Citazione:
A.V. Beylin et al., "The role of the hippocampus in trace conditioning: Temporal discontinuity or task difficulty?", NEUROBIOL L, 76(3), 2001, pp. 447-461

Abstract

It is well established that the hippocampal formation is critically involved in the acquisition of trace memories, a paradigm in which the conditioned (CS) and unconditioned stimuli (US) are separated by a temporal gap (Solomon et al., 1986). The structure is reportedly not critical for the acquisition of delay memories, where the CS and the US overlap in time (Berger & Orr. 1983; Schmaltz & Theios, 1972). Based on these results, it is often stated that the hippocampus is involved in "filling the gap" or otherwise associating the two stimuli in time. However, in addition to the presence of a temporal gap, there are other differences between trace and delay conditioning. The most apparent difference is that animals require many more trials to learn the trace task, and thus it is inherently more difficult than the delay task. Here, we tested whether the hippocampus was critically involvedin delay conditioning, if it was rendered more difficult such that the rate of acquisition was shifted to be analogous to trace conditioning. Groups of rats received excitotoxic lesions to the hippocampus, sham lesions or were left intact. Using the same interstimulus intervals (ISI), control animals required more trials to acquire the trace than the delay task. As predicted, animals with hippocampal lesions were impaired during trace conditioning but not delay conditioning. However, when the delay task was rendered more difficult by extending the ISI (a long delay task), animals with hippocampal lesions were impaired. In addition, once the lesioned animal learned the association between the CS and the US during delay conditioning, it could learn and perforin the trace CR. Thus, the role of the hippocampus in classical conditioning is not limited to learning about discontiguous events in time and spaced rather the structure can become engaged simply as a function of task difficulty. (C) 2001 Academic Press.

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Documento generato il 06/04/20 alle ore 04:35:57