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Titolo:
Effects of early hippocampal lesions on trace, delay, and long-delay eyeblink conditioning in developing rats
Autore:
Ivkovich, D; Stanton, ME;
Indirizzi:
US EPA, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711US EPA, Res Triangle Pk, NC 27711 USA Duke Univ, Durham, NC 27706 USA Duke Univ Durham NC USA 27706Duke Univ, Durham, NC 27706 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 426 - 446
SICI:
1074-7427(200111)76:3<426:EOEHLO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; EYELID RESPONSES; INFANT RAT; RABBITS; ONTOGENY; MEMORY; DISCRIMINATION; DISRUPT; ALTERNATION; EXPOSURE;
Keywords:
learning; memory; ontogeny; development; hippocampus; classical conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ivkovich, D Wright State Univ, Dept Psychol, 3640 Colonel Glenn Highway, Dayton, OH 45435 USA Wright State Univ 3640 Colonel Glenn Highway Dayton OH USA 45435
Citazione:
D. Ivkovich e M.E. Stanton, "Effects of early hippocampal lesions on trace, delay, and long-delay eyeblink conditioning in developing rats", NEUROBIOL L, 76(3), 2001, pp. 426-446

Abstract

The effects of bilateral hippocampal aspiration lesions on later acquisition of eyeblink conditioning were examined in developing Long-Evans rat pups. Lesions on postnatal day (PND) 10 were followed by evaluation of trace eyeblink conditioning (Experiment 1) and delay eyeblink conditioning (Experiment 2) on PND 25. Pairings of a tone conditioned stimulus (CS) and periocular shock unconditioned stimulus (US, 100 ms) were presented in one of threeconditioning paradigms: trace (380 ras CS, 500 ms trace interval, 880 ms interstimulus interval [ISI]), standard delay (380 ms CS, 280 ms ISI), or long delay (980 ms CS, 880 ms ISI). The results of two experiments indicated that hippocampal lesions impaired trace eyeblink conditioning more than either type of delay conditioning. In light of our previous work on the ontogeny of trace, delay and long-delay eyeblink conditioning , (Ivkovich, Paczkowski, & Stanton, 2000, showing that trace and long-delay eyeblink conditioning had similar ontogenetic profiles, the current data suggest that during ontogeny hippocampal maturation may be. more important for the short-term memory component than for the long-ISI component of trace eyeblink conditioning. The late. development of conditioning over long ISIs may depend on a separate process such as protracted development of cerebellar Cortex. (C) 2001 Academic Press.

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Documento generato il 31/03/20 alle ore 09:31:30