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Titolo:
Lesions in the central nucleus of the amygdala: Discriminative avoidance learning, discriminative approach learning, and cingulothalamic training-induced neuronal activity
Autore:
Smith, DM; Monteverde, J; Schwartz, E; Freeman, JH; Gabriel, M;
Indirizzi:
Univ Illinois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois, Program Neurosci, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Program Neurosci, Urbana, IL 61801 USA Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 a, Dept Psychol, Iowa City, IA 52242 USA Univ Illinois, Beckman Inst, Neuronal Pattern Anal Grp, Urbana, IL 61821 USA Univ Illinois Urbana IL USA 61821 Pattern Anal Grp, Urbana, IL 61821 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 403 - 425
SICI:
1074-7427(200111)76:3<403:LITCNO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; CINGULATE CORTEX; LIMBIC THALAMUS; BASAL FOREBRAIN; UNIT-ACTIVITY; RABBITS; PROJECTIONS; FEAR; STIMULUS; BEHAVIOR;
Keywords:
amygdala; cingulate cortex; limbic thalamus; avoidance learning; approach learning; discrimination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Gabriel, M Univ Illinois, Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA Univ Illinois 405 N Mathews Urbana IL USA 61801 a, IL 61801 USA
Citazione:
D.M. Smith et al., "Lesions in the central nucleus of the amygdala: Discriminative avoidance learning, discriminative approach learning, and cingulothalamic training-induced neuronal activity", NEUROBIOL L, 76(3), 2001, pp. 403-425

Abstract

The amygdala is critically involved in discriminative avoidance learning. Large lesions of the amygdala block discriminative avoidance learning and abolish cingulothalamic training-induced neuronal activity. These results indicated that amygdalar processing is critical for cingulothalamic plasticity. The larger lesions did not allow differentiation of the specific functioning of various amygdalar nuclei. Anatomical analysis showed that damage inthe central (CE) nucleus of the amygdala was correlated with the severity of the behavioral deficit. The present study was carried out to determine whether smaller lesions, centered in the CE nucleus, would impair discriminative avoidance learning and block cingulothalamic plasticity. In addition, the possible role of the CE nucleus in appetitively motivated discriminative approach learning was examined for the first time. New Zealand White rabbits with CE nuclear lesions were first trained in the discriminative approach task. After attaining asymptotic performance, discriminative avoidance training sessions were alternated with continuing approach training sessions, one session each day. The rabbits with lesions were severely impaired in avoidance learning but showed no impairment of approach learning. Surprisingly, the attenuating effects of the lesions on cingulothalamic training-induced neuronal activity were more prevalent during approach learning than during avoidance learning. These results indicated that avoidance learning can be impaired by lesions centered in the CE nucleus that leave cingulothalamic plasticity largely intact and that the CE nucleus is involved in extra-cingulothalamic learning processes. (C) 2001 Academic Press.

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Documento generato il 29/03/20 alle ore 07:58:56