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Titolo:
Is there savings for Pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats?
Autore:
Maren, S;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 268 - 283
SICI:
1074-7427(200111)76:3<268:ITSFPF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATED STARTLE; TEMPORAL GRADIENT; CENTRAL NUCLEUS; MEMORY; ACQUISITION; CONSOLIDATION; MECHANISMS; PLASTICITY; EXPRESSION; COMPLEX;
Keywords:
amygdala; NMDA; lesion; overtraining; memory; savings conditioning; freezing; fear; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 525 E Univ Ave, Ann Arbor, MI 48109 USA Univ Michigan 525 E Univ Ave Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
S. Maren, "Is there savings for Pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats?", NEUROBIOL L, 76(3), 2001, pp. 268-283

Abstract

Considerable evidence indicates an important role for amygdaloid nuclei inboth the acquisition and expression of Pavlovian fear conditioning. Recentreports from my laboratory have focused on the impact of neurotoxic lesions of the basolateral complex of the amygdala. (BLA) on conditional freezingbehavior in rats. In these studies, I have observed severe effects of posttraining BLA lesions on the expression of conditional freezing even after extensive presurgical overtraining (25-75 trials). Moreover, I have found noevidence for sparing of fear memory (i.e., savings) in these rats when I assess their rate of reacquisition relative to BLA rats receiving minimal training (1 trial). In these experiments, freezing behavior was assessed using a conventional time-sampling procedure and expressed as a response probability. Although this measure is well established in the literature, it is conceivable that it is not sensitive to spared memory in rats, with BLA lesions. To address, this issue, I present a more detailed analysis of freezingbehavior that quantifies latency to freeze, the number of freezing bouts-the duration of freezing bouts, and the probability distribution of bout lengths. I also include control data from untrained (no-shock) rats. Consistent with my earlier reports, I find no evidence of savings of fear memory in rats with neurotoxic BLA lesions using several measures of freezing behavior. These results reiterate the conclusion that fear memory, as it is expressed in freezing behavior, requires neurons in the BLA. (C) 2001 Academic Press.

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Documento generato il 31/03/20 alle ore 04:47:35